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Serotonergic phase shifts of the mammalian circadian clock effects of tetrodotoxin and high magnesium

, : Serotonergic phase shifts of the mammalian circadian clock effects of tetrodotoxin and high magnesium. Brain Research 573(2): 336-340

The mammalian circadian clock in the suprachiasmatic nuclei (SCN) can be phase-shifted in vitro by the serotonin agonist quipazine. Here we show that quipazine resets the SCN clock in the presence of tetrodotoxin or 10 mM Mg2+, treatments that block Na+ action potentials and Ca2+ channels, respectively. These results support the hypothesis that quipazine resets the clock by stimulating receptors located on clock elements rather than on cells afferent to the clock.


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