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Serum trypsin protein amidase activity a method for its determination and clinical application

, : Serum trypsin protein amidase activity a method for its determination and clinical application. Medical Journal of Kinki University 16(2): 251-260

The conditions for separate determination of trypsin-protein amidase (TPA) activity of .alpha.-1-antitrypsin (.alpha. 1AT) in the presence of .alpha.-2-macroglobulin were studied. Prior methylamine treatment of serum inactivated .alpha.-2-macroglobulin, but not .alpha. 1AT. TPA activities of .alpha. 1AT in sera of 85 patients with various cancers, 101 noncancerous patients and 42 healthy subjects were measured. The activities markedly increased in most cases of the advanced stage of gastric cancer as well as pancreatic and hepatic cancers. The activity was also significantly elevated in the early stage of gastric cancer (171.4 .+-. 24.6 U/ml n = 18) as compared with the healthy subject (143.2 .+-. 29.2 U/ml n = 41, p < 0.001). The TPA activity was increased in 40% of noncancerous liver diseases. However, no significant relation was found, between the TPA activity and serum GOT, GPT or choline esterase.


Other references

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Fitchett, J.R., 2008: Facial reconstruction--the impact of facial allograft transplantation on surgery. International Journal of Surgery 6(6): 439-440

Jaishree, J.; Kumaresan, S.; Sudha, S.; David, J.; Kulkarni, C., 2003: Individual and combined effects of N6-cyclopentyladenosine, flunarizine and diazepam on aminophylline-induced recurrent generalized seizures in mice. Protective effects of anticovulsant agents, N6-cyclopentyladenosine (CPA) and flunarizine (FLN) against aminophylline (AMPH) (280 mg/kg)-induced convulsions were tested in different groups of mice. All drugs were administered by intraperitoneal ro...

Noda, T.; Take, T.; Watanabe, T.; Abe, J., 1970: The structure of bostrycin. Bostrycin, a novel tetrahydroanthraquinone pigment1 has been isolated from cultures of Bostryconema alpestre cesati.Structure I is proposed for this pigment based on chemical and spectroscopic evidence2 and X-ray diffraction study.3

Singer, Jacob, 1869: Systematisches Verzeichniss der Familien, Gattungen und Arten der Regensburger Orthopteren. The Recorder has not seen this paper; but, according to information received, it contains tabular descriptions of 47 known species from the locality indicated. It is favourably noticed by Zeller in the Stett. ent. Zeit. xxxi. p. 224.

Hellings, J.; Lass, M.; Apted, J.; Mead, I.; Rudrum, M., 2011: Delivering London 2012; geotechnical enabling works. Selecting the Stratford site for the London 2012 Olympic and Paralympic Games provided an opportunity to regenerate a rundown area of historical industrial development and dereliction, as well as remediate the significant levels of contamination t...

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Furukawa, T.; Kubota, T.; Watanabe, M.; Nishibori, H.; Kuo,; Saikawa, Y.; Kase, S.; Tanino, H.; Teramoto, T., 1993: A suitable model for experimental liver metastasis of human colon cancer xenografts using mice with severe combined immunodeficiency. Studies on liver metastasis of human colon cancer are limited because of a lack of suitable animal models. In this study, the usefulness of mice with severe combined immunodeficiency (SCID), which congenitally lack functional T and B lymphocytes,...

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