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Specific immunological unresponsiveness to bacterial lipopolysaccharides develops in a cyclic manner

, : Specific immunological unresponsiveness to bacterial lipopolysaccharides develops in a cyclic manner. Infection and Immunity 57(7): 2253-2255

Prior exposure (priming) of BALB/cByJ mice to a low dose of lipopolysaccharide derived from Escherichia coli 055 or Serratia marcescens, followed by immunization with an optimally immunogenic dose of the same lipopolysaccharide 2 to 30 days later, results in the expression of substantially reduced antibody responses. Such unresponsiveness, which is antigen specific, occurs in a cyclic manner with time after priming.


PMID: 2471694

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