Specific immunological unresponsiveness to bacterial lipopolysaccharides develops in a cyclic manner
Elkins, K.L.; Stashak, P.W.; Baker, P.J., 1989: Specific immunological unresponsiveness to bacterial lipopolysaccharides develops in a cyclic manner. Infection and Immunity 57(7): 2253-2255
Prior exposure (priming) of BALB/cByJ mice to a low dose of lipopolysaccharide derived from Escherichia coli 055 or Serratia marcescens, followed by immunization with an optimally immunogenic dose of the same lipopolysaccharide 2 to 30 days later, results in the expression of substantially reduced antibody responses. Such unresponsiveness, which is antigen specific, occurs in a cyclic manner with time after priming.