+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Spectroscopic kinetic and semiempirical molecular orbital studies on 8 aminoadenosines 8 methylaminoadenosines and 8 dimethylaminoadenosines

, : Spectroscopic kinetic and semiempirical molecular orbital studies on 8 aminoadenosines 8 methylaminoadenosines and 8 dimethylaminoadenosines. Tetrahedron 47(26): 4693-4708

Kinetic studies on acidic depurination of 8-aminoadenosine, 8-methylaminoadenosine, and 8-dimethylaminoadensine show their relative rates are respectively 2.7, 2 and 429-fold with respects to adenosine. Structural consequence of 8-amino, 8-methylamino or 8-dimethylamino group in the 8-substituted purine nucleosides have been therefore investigated in order to delineate the influence of these 8-amino substitutents on the relative rate of cleavage of glycosyl bond under acidic condition by both 15N- and 1H-NMR spectroscopy in neutral and acidic solutions. 15N-NMR studies showed that the relative amount of protonation at N1 in 8-amino adenosine and 8-methylaminoadenosine are 66% (44% N7H+) and 85% (15% N7H+), respectively, while it is 66% (4% N7H+) in case of 8-dimethylaminoadenosine. 1H-NMR studies also showed some differences in conformation of sugar moiety of nucleosides in acidic solution in comparison with their conformations in neutral solution. Semiempirical Molecular Oribital calculations have been used to throw light on steric and electronic factors dictated by 8-amino, 8-methylamino or 8-dimethylamino group across C8-N8 bond that control the stabilization of N7H+ versus N1H+ species. Results from these Semiempirical Molecular Orbital calculations have been subsequently assessed with those obtained by 15N-NMR-studies.


Other references

Starup-Linde, J.; Eriksen, S.A.; Lykkeboe, S.; Handberg, A.; Vestergaard, P., 2015: Biochemical markers of bone turnover in diabetes patients--a meta-analysis, and a methodological study on the effects of glucose on bone markers. This study examined whether markers of bone turnover differ between individuals with and without diabetes. Bone markers showed heterogeneity between studies and were discrepant for markers of bone creation and markers of bone degradation. Bone mar...

Ametov, A.S.; Gubina, E.V., 1999: Metabolic effects of berlipril-5 in patients with non-insulin-dependent diabetes mellitus and arterial hypertension. Aim. To study metabolic effects of berlipril-5 (enalapril) in patients with non-insulin-dependent diabetes mellitus (NIDDM) and arterial hypertension (AH). Materials and methods. 24 patients with NIDDM and AH were divided into three groups by the...

Duchene Marullaz, P.; Schaff, G.; Lautier, F.; Delort, P., 1967: About sympathominietic effects of dichloroisoproterenol. The cardiac rhythm of anesthetized dogs increased from 70 to 190 systoles per min. by the dose of 2,5, 5 mg/kg DCI and registered by a telemeter is progressively corrected within 7 and 11 hr. With the amount of 10 mg/kg the rhythm is accelerated u...

Danchin E.; Nelson J.B., 1991: Behavioral adaptations of cliff nesting in the kittiwake rissa tridactyla convergences with the gannet sula bassana and the black noddy anous tenuirostris. Since Cullen's (1957) classic paper, many new Kittiwake (Rissa tridactyla) displays have been described and the significance of some others have been reinterpreted. These advances in our knowledge of the Kittiwake's repertoire cast furth...

Heinsdorf, D., 1978: The effect of two fertilizers nitrogen and potassium on nutrition and growth of young pine stands on sandys oils in the lowlands of the German Democratic Republic. Beitrage fur die Forstwirtschaft2(2): 65-72

Monnis, M.; Dewan, R.; Sarin, S.K.; Chuttani, H.K., 1988: Effects of sucralfate on gastric acid secretion and duodenal ulcer healing. Journal of the Association of Physicians of India 36(4): 251-253

Decoteau, W.E.; Kesner, R.P.; Gilbert, P., 1995: The role of the hippocampus in reducing spatial interference. Society for Neuroscience Abstracts 21(1-3): 1943

Nissim Rafinia, M.; Kerem, B., 2001: The effect of cellular and viral splicing factors on the level of normal CFTR RNA. American Journal of Human Genetics 69(4 Supplement): 650, October

Diglio C.A., 1985: Cell line a 549 enhancement of differentiated type 2 cell function using mitomycin c. Journal Of Cell Biology Part 2: 489a

Dzuvic, A.S.ric, K.N.dazdin, M.L.kvancic, H., 1981: Nature and intensity of micromorphological changes in kidneys and liver of rabbits hyperimmunized by various serotypes of Leptospira. Veterinaria zbornik radova iz oblasti animalne proizvodnje = periodical on the animal production0(2): 219-229