+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Splenic lymphoma with villous lymphocytes natural history and response to therapy in 50 cases

, : Splenic lymphoma with villous lymphocytes natural history and response to therapy in 50 cases. British Journal of Haematology 78(2): 206-209

We studied the natural history and response to treatment in 50 patients with splenic lymphoma with villous lymphocytes followed for a minimum of 6 months and up to 15 years (median 3.7 years). The disease occurs in the elderly (median 68 years) and affects males more than females (M/F ratio 1.77). The median survival for the group was not reached but 82% were surviving at 3 years and 78% at 5 years. Twelve patients (24%) died, one-third of deaths were disease related (four patients) and one-half were due to cardiovascular disease or another malignancy (six patients). The outcome was worse for males (31% died) than females (11% died). Fourteen patients were not treated and 10 remain alive between 1 and 6 years from diagnosis. The remaining patients were treated by chemotherapy, splenic irradiation or splenectomy. The response to chemotherapy was poor and only eight of 22 (36%) patients treated achieved a good response. Splenic irradiation was employed in seven patients and three benefited from it. Splenectomy seems to be the treatment of choice, with significant improvement seen in 19 of 20 patients with one post-operative death. This response, lasting from 6 months to 7 years (median 4 years), was seen irrespective of whether splenectomy was the initial treatment or used later in management.


PMID: 2064958

DOI: 10.1111/j.1365-2141.1991.tb04417.x

Other references

Andres, HG., 1982: Die Gammaridea (Crustacea: Amphipoda) der Deutschen Antarktis-Expeditionen 1975/76 und 1977/78 2. Eusiridae. Mitteilungen aus dem Hamburgischen Zoologischen Museum und Institut, 79: 159-185

Dognon, A.; Dutreix, J., 1951: Electroradiology in 1951. Paris Medical 41(7): 85-95

Jacobsen N.O., 1984: Estimates of pup production age at 1st parturition and natural mortality for hooded seals cystophora cristata in the west ice. An analysis of the population of hooded seals breeding in the West Ice near Jan Mayen was carried out on the basis of catch statistics for 1946-1978 and age samples comprising a total of 5094 breeding females 4 yr old and older. A deterministic po...

Dobrev, I., 1961: Surgical therapy of suppurative diseases of the lung. Khirurgiia 14: 136-137

Mittal, S.; Wightman, J.A., 1989: An inert dust protects stored groundnut from insect pests. An attapulgite-based clay dust mixed with groundnut seeds at 10 g/2 kg seed controlled Corcyra cephalonica and Tribolium castaneum for up to 120 days. The treatment of pods infested with Caryedon serratus with 0.5% (w/w) dust afforded some control...

Sugimoto, T.; Katsurada, K.; Kojima, G.; Ogino, H., 1968: Duodenal injury caused by abdominal contusion. Geka Chiryo. Surgical Therapy 19(6): 861-866

Wang, Y-Yuan.; Ma, Z-Yong.; Kan, X-Hong.; Liu, F-Fang.; Li, L.; Zhang, Y., 2010: RETRACTED: Assessment of manidipine on left ventricular function in Chinese hypertensive patients using a tissue Doppler imaging (TDI) Tei index. The Publisher regrets that this article is an accidental duplication of an article that has already been published, The duplicate article has therefore been withdrawn.

Huijts, T.; Reeves, A.; McKee, M.; Stuckler, D., 2016: The impacts of job loss and job recovery on self-rated health: testing the mediating role of financial strain and income. Is regaining a job sufficient to reverse the harmful impacts on health of job loss during the Great Recession? We tested whether unemployed persons who found work within 1 year of job loss experienced a full recovery of their health. Additionally,...

Kimura, D.; Nakamura, T.; Kaino, K.; Itoh, T.; Toba, T.; Hori, Y.; Shimizu, Y., 2001: In vivo tissue engineering of the common bile duct using polyglycolic acid -collagen composite graft in canine model. International Journal of Artificial Organs 24(8): 538, August

Dottori, O., 1969: Action of nitrous oxide-oxygen-curage analgesia on the cardiovascular system. Experimental and clinical study. Minerva Anestesiologica 35(10): 1024-1036