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Study of the cyclic amp influence of calcium currents in mollusc neurons possessing different sensitivity of their calcium conductance to serotonin action

, : Study of the cyclic amp influence of calcium currents in mollusc neurons possessing different sensitivity of their calcium conductance to serotonin action. Neirofiziologiya 22(5): 605-612

The action of cAMP (100 .mu.M) and serotonin (5-HT, 1-10 .mu.M) on the calcium current (ICa) in intracellularly perfused Helix pomatia neurons was studied with voltage clamp method. Three types of 5-HT-induced changes in the calcium current were observed in different cells: reversible blockade, increase and no changes in the current amplitude. Intracellular introduction of exogenous cAMP (100 .mu.M) affected ICa only in cells with the stimulatory effect of 5-HT; cAMP-induced increase in the current amplitude was not additive to that elicited by 5-HT while both of these effects were similarly potentiated by cyclic nucleotide-phosphodiesterase inhibitor. The data presented show that the stimulatory action of 5-HT on the potential-activated calcium current is mediated by an increase in intracellular cAMP. Existence of two types of calcium channels differing in their dependence on cAMP metabolism is suggested in the snail neurons. The presence of the cAMP-dependent calcium channels seems to correlate with the existence of the definite type of 5-HT receptors in the cell membrane. A new approach to the investigation of isolated neurons is suggested: their functional identification.


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