+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The effects of furosemide on the subcommissural organ cells in rats

, : The effects of furosemide on the subcommissural organ cells in rats. Prace Naukowe Uniwersytetu Slaskiego w Katowicach (1101): 9-24

In this study we tried to confirm that SCO is involved in the processes of osmoregulation. Therefore, we analysed the secretory activity of SCO cells in relation to the activities of the hypothalamic neurosecretory nuclei in while rats after the experimental administration of a dehydrating agent, i.e. furosemide. Males of white rats of the Wistar/Bog. line were used. The animals were 1 month old. Three groups were established. In the control group I (K1) the rats received as much food and drinking water was required. In the control group II (K2) the rats were deprived of water but additionally had a dose of 1 mg/24 hr of physiological saline injected interperitoneally. In the experimental group (E) the rats did not receive any water but additionally had a dose of 0.0097 ml/l g b.w. of furosemide injected interperitoneally. The experiment lasted for 5 days. The sectioned material was stained according to Gomori-Bargmann's and Bock's methods. Functional changes in cells were evaluated karyometrically. The metabolic processes which are intrinsic of the secretory activity of cells were analysed by using histochemical reactions revealing the activities of SDH, LDH, G6-PD and TPP. The changes observed after the experimental administration of furosemide suggest that dehydration exerts (to acertain degree) an inhibitory effect on the secretory activity of SCO cells. Our results seem to confirm the fact that ependymal SCO cells are actively engaged in the processes of osmoregulation.


Other references

Ageno, W.; Ambrosini, F.; Barlocco, E.; Imperiale, D.; Dentali, F.; Posa, F.; Mera, V.; Steidl, L.; Venco, A., 2001: A model to assess the possibility to safely treat with warfarin elderly patients with atrial fibrillation. European Heart Journal 22(Abstract Supplement): 605, September

Doyle, T.W.; Westbrooks, R.; Krauss, K., 2009: Landscape simulation model for invasive species spread and detection. Scientific Investigations Report: 14

Mercer, C.W.L., 1994: Sago grub production in Labu swamp near Lae, Papua New Guinea. A brief report of a study conducted on the inland margin of Labu swamp, where the thorny stemmed sago palm species Metroxylon rumphii [M. sagu] is used almost exclusively by the Labu people for raising the grub of the palm weevil Rhynchophorus fer...

Muench, C.; Katzberg, N.; Seedorf, U.; Scheibner, J.; Stange, E.F.; Fuchs, M., 2001: Impaired feedback inhibition of oxysterol 7a-hydroxylase in mice with homozygous disruption of the sterol carrier protein 2 gene. Hepatology 34(4 Pt 2): 353A, October

Oja, S.S.; Saransaari, P., 2000: Ammonia effects on ionotropic glutamate receptors. Proceedings of the Western Pharmacology Society 43: 25-26

Thanos S., 1992: Sick photoreceptors attract activated microglia from the ganglion cell layer a model to study the inflammatory cascades in rats with inherited retinal dystrophy. Understanding of neuron-glial interactions in neurodegenerative diseases remains limited, but is of crucial importance for unravelling the etiology of such disorders both in humans and in animals. The present work employed a new, function-dependen...

DePasse, J.Mason.; Haglin, J.; Eltorai, A.E.M.; Mulcahey, M.K.; Eberson, C.P.; Daniels, A.H., 2017: Orthopedic In-Training Examination Question Metrics and Resident Test Performance. First administered in November 1963, the orthopedic in-training examination (OITE) is now distributed to more than 4000 residents in over 20 countries and has become important for evaluation of resident fund of knowledge. Several studies have asse...

Scola, E., 1966: Current status of surgery of deafness by stapedial technics. Our current system and results and personal technic. Acta Oto-Rino-Laringologica Ibero-Americana 17(1): 31-38

Perni, R.B.; Conway, S.C.; Ladner, S.K.; Zaifert, K.; Otto, M.J.; King, R.W., 2000: Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication. A non-nucleoside class of compounds that inhibits the replication of hepatitis B virus (HBV) in cell culture has been discovered. A series of substituted analogues of phenylpropenamide 6 has been prepared and evaluated in the HepAD38 cellular assa...

Shiosaki, S.; Kuramoto, M.; Toita, R.; Mori, T.; Niidome, T.; Katayama, Y., 2011: A hydrophilic polymer grafted with a histone tail peptide as an artificial gene regulator. In chromatin, gene transcription is regulated through posttranslational modifications on the histone N-terminal tail sequences, typically an acetyl group modification on lysine residues. To realize a simple model of the gene regulation of chromati...