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The response of inhibin to human chorionic gonadotropin is decreased in senescent men compared with young men


, : The response of inhibin to human chorionic gonadotropin is decreased in senescent men compared with young men. Journal of Endocrinology 123(2): R9-R12

Inhibin and testosterone were measured in the serum of young and old men with proven fertility before and after stimulation with human chorionic gonadotrophin (hCG) in order to characterize endocrinological changes in senescence further. While there was a significant increase of both hormones in all young men, there was a decreased response of serum testosterone and an insignificant increase in inhibition in the older men. Although basal hormone levels and ejaculate parameters were not different, hCG stimulation revealed that there were decreased secretory capacities of Leydig as well as of Sertoli cells in old age.

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PMID: 2607244


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