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The selective influence of neuroleptics on dopamine dependent behavioral disturbances in rats in the extrapolated escape test


, : The selective influence of neuroleptics on dopamine dependent behavioral disturbances in rats in the extrapolated escape test. Byulleten' Eksperimental'noi Biologii i Meditsiny 110(11): 506-508

The low doses of neuroleptics restored the ability of I-DOPA treated rats to escape behavior from actue stress-situation (in the extrapolatory escape test). Non-antipsychotic benzamides and phenothiazine, antidepressants and benzodiazepine tranquilizers were inactive. On the whole, the effectivity of the neuroleptics was in accordance with clinical data. The loss of ability to escape in I-DOPA treated rats was accompanied by stereotypes hyperlocomotion in the water. Various psychotropic drugs decreased only hyperactivity without the influence on escape behaviour. Both forms of behavioral pathology were prevented by central aromatic acid decarboxylase inhibitor. However, the loss of ability to escape behavior only is selective and sensitive to neuroleptics action.

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