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Transcriptional repression by a novel member of the bZIP family of transcription factors

, : Transcriptional repression by a novel member of the bZIP family of transcription factors. Molecular and Cellular Biology 12(7): 3070-3077

We describe here a novel member of the bZIP family of DNA-binding proteins, designated E4BP4, that displays an unusual DNA-binding specificity which overlaps that of the activating transcription factor family of factors. When expressed in a transient transfection assay with a suitable reporter plasmid, E4BP4 strongly repressed transcription in a DNA-binding-site-dependent manner. Examination of a series of deletion mutants revealed that sequences responsible for the repressing potential of E4BP4 lie within the carboxyl-terminal region of the protein. No similarity was found between this region and the repressing domains of other known eukaryotic transcriptional repressors.


PMID: 1620116

DOI: 10.1128/mcb.12.7.3070

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