+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Treatment of peripheral arteriopathies with a new low weight heparin. Results of a double blind, controlled study

, : Treatment of peripheral arteriopathies with a new low weight heparin. Results of a double blind, controlled study. Panminerva Medica 33(4): 197-204

Forty out-patients, 28 males and 12 females (mean age: 50.75 .+-. 5.28); (range: 39 to 67) suffering from peripheral arteriopathies of the lower limbs, were admitted to the study. The treatment, assigned at random in a balanced way, was performed with an LMWH or with placebo (one vial by s.c. route/day, for a mean duration of 6 months). During the therapy we observed a gradual symptomatology, claudictio intermittens and Winsor index improvement in patients treated with the active drug, in comparison with evident stationarity in patients treated with placebo. The haemocoagulative balance control, performed through the determination of Activated Partial Thromboplastin Time, of Xa factor inhibition and of plasminogen, confirmed the poor influence of the treatment with LMWH both on haemostatic function and on a possible increment in haemorrhagic risk. Systemic and local (at the injection site) tolerability were good in particular as to haematoma frequency.


PMID: 1806878

Other references

Bradley, J.L.; Piatak, M.; Lane, J.A.; McGuire, P.M., 1989: Site-directed mutagenesis at amino terminus of recombinant ricin A chain. Successful immunotoxin therapy may depend upon reduction of the size of the components in order to decrease antigenicity and rate of clearance. In initial attempts to modify the A chain of ricin by deletion analyses within a prokaryotic expression...

Kitsopanidis, Gj, 1987: Thirty years (1955-1985) of farm management research in Greece. Staff paper University of Florida Food and Resource Economics Department Institute of Food and Agricultural Sciences: 87 (307)

Baron, S.; Friedman, R.M.; Buckler, C.E., 1963: Properties of poliovirus inhibitor from monkey brain. Properties of monkey brain suspensions which are inhibitory for polioviruses coincided with properties of cell receptor site material. Inhibitory material did not directly affect host cells but was bound to virus. A possible role of receptor in el...

Yamada, H.; Hirai, S.; Ikegami, S.; Kawarada, Y.; Okuhara, E.; Nagano, H., 1985: The fate of DNA originally existing in the zygote nucleus during achromosomal cleavage of fertilized echinoderm eggs in the presence of aphidicolin: microscopic studies with anti-DNA antibody. In fertilized echinoderm eggs, the male and female pronuclei fuse to form the diploid nucleus even in the presence of aphidicolin, a specific inhibitor of eukaryotic DNA polymerase-.alpha.. The subsequent first cleavage is independent of chromosom...

Huebner, J.; Marienfeld, S.; Abbenhardt, C.; Ulrich, C.; Muenstedt, K.; Micke, O.; Muecke, R.; Loeser, C., 2014: Counseling patients on cancer diets: a review of the literature and recommendations for clinical practice. Many cancer patients use cancer diets. We listed 13 cancer diets simulating an internet search for which we systematically reviewed clinical data. In the next step we derived recommendations on counseling patients using a Delphi process. We evalua...

Shapiro, D.L., 1970: The human element--a problem in psychiatric assessment. American Journal of Psychiatry 126(12): 1795-1795

Lama, P.J., 2006: Topical beta-adrenergic blockers and glaucoma: a heart-stopping association?. Ophthalmology 113(7): 1067-1068

Whitworth, G.E.; Zandberg, W.F.; Clark, T.; Vocadlo, D.J., 2010: Mammalian Notch is modified by D-Xyl-alpha1-3-D-Xyl-alpha1-3-D-Glc-beta1-O-Ser: implementation of a method to study O-glucosylation. Notch is a key cell surface protein receptor that is a vital component of intercellular signaling occurring during development. The O-glucosylation of the extracellular Notch epidermal growth factor-like (EGF) repeats has recently been found to pl...

Jimenez, E.C.; Olivera, B.M., 2010: Divergent M- and O-superfamily peptides from venom of fish-hunting Conus parius. Six novel peptides from the piscivorous cone snail, Conus parius were purified by reverse-phase HPLC fractionation of crude venom. With the use of matrix-assisted laser desorption ionization mass spectrometry and standard Edman sequencing methods,...

Issar A., 1987: Efficiency as a function of hydrological stress in groundwater resources management. Australian Water Resources Council Conference Series 13: 119-124