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Trh in the pancreas of newborn rats from streptozotocin treated mothers


, : Trh in the pancreas of newborn rats from streptozotocin treated mothers. Life Sciences 44(12): 779-788

The effect of maternal diabetes (induced by i.p. injections of 40-50 mg/kg BW Streptozotocin on the day of mating) on TRH in the pancreas of newborn rats was studied. Determination of peptide alpha amidation activity and TRH precursor level on the day of birth revealed decreased biosynthesis of TRH resulting in profoundly (10 times) lower pancreatic TRH and TRH-OH concentration in pups of diabetic rats. Pancreatic His-Pro-diketopiperazine (His-Pro-DKP) remained unaffected by maternal diabetes. The depression of pancreatic TRH was less profound 24 in later, and even elevated TRH was measured in the pancreas of pups of diabetic mothers on postnatal day 5. Short term postnatal starvation or nursing of intact pups by the diabetic foster mother did not effect pancreatic TRH. It could be postulated that postnatal TRH development in the rat pancreas is retarded by maternal diabetes, while His-Pro-DKP remains unaltered.

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Other references

Causeret, J.; Hugot, D.; Flanzy, M., 1956: Effects of ethyl alcohol on nitrogen balance in the rat. Comptes Rendus Hebdomadaires des Seances de L'academie des Sciences 243(3): 313-315

Mendez, J.; Adkins, J., 2008: Coastal ocean iron time series. Geochimica et Cosmochimica Acta 72.12S: A619

Flood, C.; Tobin, A., 1978: The rural production school: guidelines for the formulation of models in Argentina. One of a series on rural education, the paper aims to present the conceptual framework for establishing rural production schools. It first considers key elements in the rural education system (organizational, methodological, etc.), then analyzes t...

Martinez, F.J.; McCune, W.Joseph., 2006: Cyclophosphamide for scleroderma lung disease. New England Journal of Medicine 354(25): 2707-2709

Tsyvkin, M.V.; Rameshvili, T.E., 1969: On the technique of carotid angiography in axial projection. Voprosy Neirokhirurgii 33(4): 16-18

Nakada, H.; Narimatsu, H.; Tsubokura, M.; Murashige, N.; Matsumura, T.; Kodama, Y.; Kishi, Y.; Kami, M., 2010: Risk of fatal adverse events after H1N1 influenza vaccination. Clinical Infectious Diseases 50(11): 1548-1549

Basavaraj, H.R., 1965: A Study On Some Aspects Of Intrauterine Device. Journal of the Indian Medical Association 44: 620-622

Mandelbaum, B.; Mithoefer, K.; Peterson, L.; Saris, D.; Dvorák, J., 2012: Cartilage Issues in Football (Soccer): An Executive Summary of the Fédération Internationale de Football Association (FIFA)/ International Cartilage Repair Society (ICRS) Initiative. Cartilage 3(1 Suppl): 6s-10s

Martinet, C.; Gat, Y. le; Lafargue, I.; Detot, I.; Bruchet, P., 1997: Observations on hibernation aspects of the codling moth (Cydia pomonella L.). A field study and a statistical model were used during 1992-95 to analyze the effects of winter (temperature and photoperiod) on the development of Cydia pomonella. Hibernating C. pomonella were caught weekly in a non-treated French orchard and ke...

Pereiro Miguens, M.; Pereiro Ferreiros, M.M., 1982: Our experience concerning the gypseum complex. Among 2053 patients with dermatophyte infections seen during 1951-80, there were 118 cases of infection with the Microsporum gypseum complex. Other spp. isolated are tabulated. Of 60 isolates (59 from patients and 1 from soil) of the M. gypseum co...