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Using dnase in amino acid biosynthesis


, : Using dnase in amino acid biosynthesis. Khimiko-Farmatsevticheskii Zhurnal 22(11): 1370-1374

The effect was studied of pancreatic DNAse on the growth of Bacillus subtilis, Brevibacterium flavum and Escherichia coli, the producers of amino acids, as well as on the biosynthesis of some essential amino acids. Methods were developed for the most effective use of DNAse to intensify these processes. The microorganisms were cultivated under periodic and semiperiodic conditions. The effect of these regimens on the accumulation of amino acids was described. Microbial populations cultivated in the presence of DNAse possessed sufficiently high "metabolite potential." The diversity of the processes of amino acid biosynthesis makes it possible to assume the individual character of the feed of substrate loads under the obligatory use of DNAse.

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