geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

"Cytomegalovirus disease" in renal allograft recipients: is human herpesvirus 7 a co-factor for disease progression?


, : "Cytomegalovirus disease" in renal allograft recipients: is human herpesvirus 7 a co-factor for disease progression?. Journal of Medical Virology 48(4): 295-301

Fifty-six renal allograft recipients were studied prospectively for 3 months or longer after transplant. The polymerase chain reaction (PCR) was used to screen peripheral blood leucocyte (PBL) specimens for CMV, human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7) DNA (DNAemia) in 67 healthy controls and in serial (fortnightly) PBL specimens from the 56 allograft recipients. None of the healthy controls had detectable CMV DNAemia, although HHV6 and HHV7 DNAemia was found in 7% and 9% of individuals respectively. In contrast, DNAemia due to CMV, HHV6 and HHV7 was found in 50%, 36% and 39% of patients respectively, at some time during the post-transplant period. Of the 28 patients who had CMV DNAemia, eight developed "CMV disease." The risk of progression to "CMV disease" was increased in patients with concurrent DNAemia to all three viruses (relative risk 3.7; 95% CI 1.3-10.5). The relative risk of "CMV disease" for patients with concurrent CMV and HHV7 was also increased (RR = 3.5; 95% CI= 1.1-11.6), while the association between CMV and HHV6 was inconclusive (RR = 2.1; 95% CI = 0.7-6.6). The first 26 patients recruited to the study also had serial serum samples tested for antibody responses to the three viruses. "CMV disease" was associated with rising antibody titres to HHV7 (Fisher's exact test, P = 0.02), and weakly so with HHV6 (P = 0.07). It is concluded that in patients with CMV DNAemia, concurrent infection/reactivation of HHV7 (and possibly HHV6) is associated with an increased risk of progression to "CMV disease."

US$19.90

PMID: 8699160

DOI: 10.1002/(SICI)1096-9071(199604)48:4<295::AID-JMV1>3.0.CO;2-2


Other references

Wilmore, Douglas W., 1999: Overview - Fundamentals of glutamine metabolism. Journal of Parenteral & Enteral Nutrition 23(5 SUPPL ): S136, Sept -Oct

Robertson, G.S.; Doucet, J.P.; Hope, B.T.; Nestler, E.J.; Nakabeppu, Y.; Iadarola, M.J.; Wigle, N.; S.J.an, M., 1994: Truncated FosB is responsible for the long lasting increase in striatal Fos-like immunoreactivity produced by dopaminergic denervation. Society for Neuroscience Abstracts 20(1-2): 987

Tromp, E.E.; Kouwenhoven, S.T.P.; Quint, K.D.; Gmelig Meijling, K.A.; Genders, R.E., 2015: Unilateral scrotal angiomas: An expression of underlying varicocele. The current case report describes a 35-year-old man who presented with unilateral scrotal angiomas. The presence of unilateral scrotal angiomas was associated with an underlying varicocele on the ipsilateral side due to increased venous pressure....

Abbasi, K., 2009: Are working hours more frightening than swine flu?. Journal of the Royal Society of Medicine 102(5): 167-167

Reynolds R.L.; Karachewski J.A.; Fishman N.S.; Rosenbaum J.G., 1986: Magnetic properties of greigite-bearing Cretaceous strata, North Slope, Alaska. Eos, Transactions, American Geophysical Union 67(44): 923

Besse, I.M.; Madsen, M.T.; Bushnell, D.L.; Juweid, M.E., 2009: Modeling combined radiopharmaceutical therapy: a linear optimization framework. In this paper, we investigate a previously proposed mathematical model describing the effects that an innovative combined radiopharmaceutical therapy might have on the delivery of radiation to the tumor and limiting critical organs. While focused...

Beck, T.W.; Housh, T.J.; Johnson, G.O.; Cramer, J.T.; Weir, J.P.; Coburn, J.W.; Malek, M.H., 2006: Does the frequency content of the surface mechanomyographic signal reflect motor unit firing rates? A brief review. The purpose of this review is to examine the literature that has investigated the potential relationship between mechanomyographic (MMG) frequency and motor unit firing rates. Several different experimental designs/methodologies have been used to...

Anthony, D.C.; Giangaspero, F.; Graham, D.G., 1983: The spatio-temporal pattern of the axonopathy associated with the neurotoxicity of 3,4-dimethyl-2,5-hexanedione in the rat. The neurotoxicity of the gamma-diketone 3,4-dimethyl-2,5-hexanedione(DMHD) was studied to determine the distribution of the neuropathologic changes and the temporal sequence during the intoxication period and following five and 15 weeks of recover...

Mattson-DiCecca, A.A.; Reynolds, E., 2009: Update: A 59-year-old man considering implantation of a cardiac defibrillator. JAMA 302(1): 81-81

Kosmidis, M.H.; Fantie, B.D., 1993: Deficit in avoidance learning manifested by closed-head-injury survivors Impaired anticipation, attention, or ability to associate?. Journal of Clinical & Experimental Neuropsychology 15(1): 106