geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

2-NAP: A selective, hydrophilic, non-peptide CCK-A-receptor antagonist derived from the cholecystokinin C-terminal dipeptide


, : 2-NAP: A selective, hydrophilic, non-peptide CCK-A-receptor antagonist derived from the cholecystokinin C-terminal dipeptide. Bioorganic and Medicinal Chemistry Letters 3(8): 1511-1516

Analogues of the cholecystokinin (CCK) C-terminal dipeptide (32-33, Asp-Phe-NH-2) have been prepared and the structure-activity relationships of this series are described. The sodium salt of 2naphthalenesulphonyl L-aspartyl (2-phenethyl)amide, (2-NAP), displayed high affinity for CCK-A receptors by its antagonism of CCK-8-stimulated guinea-pig gallbladder contraction. In addition, 2-NAP exhibits selectivity with respect to gastrin/CCK-B receptors ( gt 300-fold) and has a low log P (-0.91, chloroform/buffer).

US$29.90


Other references

Harrison, P.; Mumford, A., 2009: Screening tests of platelet function: update on their appropriate uses for diagnostic testing. Global tests of platelet function are often used as screening tests during the laboratory investigation of individuals with suspected hemostatic defects. Because global tests of platelet function do not enable specific diagnosis of platelet disord...

Jardin, M.; Puech, J.L.; Fourtanier, G.; Joffre, F., 1985: Scanographic diagnosis of a localized form of Caroli's disease. The authors report a case of Caroli's disease, localized in the left hepatic lobe without any associated abnormality. Preoperative diagnosis of such localized forms is actually possible by the use of non invasive methods, especially computed...

Griffith D.P., 1986: Staging upper tract urinary calculi analysis of an eswl centers population. World Journal Of Urology: 252-255

Werner, E.; Monk, C., 2006: Review of forms of intersubjectivity in infant research and adult attachment. Reviews the book, Forms of Intersubjectivity in Infant Research and Adult Attachment by Beatrice Beebe, Steven Knoblauch, Judith Rustin, and Dorienne Sorter (2005). In this book, the authors use their 10 years of collaborative work to produce an i...

Cui, Z.; Chen, Y.; Xiao, Z.; Hu, M.; Lin, Y.; Chen, Y.; Zheng, Y., 2016: Long noncoding RNAs as auxiliary biomarkers for gastric cancer screening: A pooled analysis of individual studies. Long non-coding RNAs (lncRNAs) are highlighted as novel cancer biomarkers with great promise. Herein, we focused on summarizing the overall diagnostic performance of lncRNAs for gastric cancer (GC). Publications fulfilling the search criteria were...

Grossman M.I., 1974: Evidence for an oxynto pyloric reflex for release of gastrin. Gastroenterology: 837

Hawkins, R.A.; Mokashi, A.; Dejoseph, M.R.; Viña, J.R.; Fernstrom, J.D., 2010: Glutamate permeability at the blood-brain barrier in insulinopenic and insulin-resistant rats. The influence of diabetes on brain glutamate (GLU) uptake was studied in insulinopenic (streptozotocin [STZ]) and insulin-resistant (diet-induced obesity [DIO]) rat models of diabetes. In the STZ study, adult male Sprague-Dawley rats were treated...

Whittaker J.B., 1984: Responses of sycamore acer pseudoplatanus leaves to damage by a typhlocybine leafhopper ossiannilssonola callosa. A typhlocybine, O. callosa, had a mean density of only 0.02 adults per leaf on sycamore (A. pseudoplatanus) in a part of a woodland which was foraged by the ant Formica rufa, but 0.44 adults per leaf in the ant-free parts of the wood. Feeding dama...

Fu, X-bing., 2007: Adult stem cells and regenerative medicine: progress and prospect in some main fields. Zhonghua Yi Xue Za Zhi 87(17): 1153-1155

Hölttä, T.; Vesala, T.; Perämäki, M.; Nikinmaa, E., 2002: Relationships between embolism, stem water tension, and diameter changes. A model for embolism in the sapflow process was developed, in which embolism is described as a physical process linked to real physical properties of the conduits and the thermodynamic state of water. Different mechanisms leading to embolism and t...