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A point mutation in the CYTB gene of cardiac mtDNA associated with complex III deficiency in ischemic cardiomyopathy

, : A point mutation in the CYTB gene of cardiac mtDNA associated with complex III deficiency in ischemic cardiomyopathy. Biochemistry & Molecular Biology International. 40(3): 487-495

We report a high incidence of reduced respiratory Complex III activity in heart muscle concomitant with the presence of a specific mutation in cytochrome b (cytb) in patients with ischemic cardiomyopathy. This C fwdarw A mutation at nt 15452 converts the 236th residue of cytb from a leucine to isoleucine, is heteroplasmic and was observed in only 2 of 43 controls. Complex III activity is reduced ( gt 50%) in 5 of 6 patients with the C fwdarw A-15452 mutation suggesting that the cytb mutation is responsible for decreased Complex III activity and may play a role in the pathophysiology of ischemic cardiomyopathy.


PMID: 8908357

DOI: 10.1080/15216549600201053

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Hodzic, E.; McKisic, M.; Feng, S.; Barthold, S.W., 2002: Evaluation of diagnostic methods for Helicobacter bilis infection in laboratory mice. Disease-susceptible (C3H) and -resistant (B6) immunocompetent and immunodeficient (C3H-scid and B6-rag1) mice were examined up to 10 weeks after inoculation with Helicobacter bilis (a prototype species of proven virulence). Infection was monitored...

Bostock M.G.; Kennett B.L.N., 1989: The effects of three-dimensional structure on crustally guided waves. Eos, Transactions, American Geophysical Union 70(15): 391-392

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Bondarenko S.K.; Kontrimavichus V.L., 1980: Dichoanotaenia multifilamenta new species cestoda dilepididae from the black turnstone arenaria melanocephala in alaska usa. D. multifilamenta sp. nov. from the Black Turnstone, A. melanocephala (Vigors), in Alaska is described. This cestode is distinguished from other Dichoanotaenia spp. Lopez-Neyra 1944 mainly by the structure of the cirrus and of the egg. [It is comp...

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