geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A point mutation in the CYTB gene of cardiac mtDNA associated with complex III deficiency in ischemic cardiomyopathy


, : A point mutation in the CYTB gene of cardiac mtDNA associated with complex III deficiency in ischemic cardiomyopathy. Biochemistry & Molecular Biology International. 40(3): 487-495

We report a high incidence of reduced respiratory Complex III activity in heart muscle concomitant with the presence of a specific mutation in cytochrome b (cytb) in patients with ischemic cardiomyopathy. This C fwdarw A mutation at nt 15452 converts the 236th residue of cytb from a leucine to isoleucine, is heteroplasmic and was observed in only 2 of 43 controls. Complex III activity is reduced ( gt 50%) in 5 of 6 patients with the C fwdarw A-15452 mutation suggesting that the cytb mutation is responsible for decreased Complex III activity and may play a role in the pathophysiology of ischemic cardiomyopathy.

US$19.90

PMID: 8908357

DOI: 10.1080/15216549600201053


Other references

Hodzic, E.; McKisic, M.; Feng, S.; Barthold, S.W., 2002: Evaluation of diagnostic methods for Helicobacter bilis infection in laboratory mice. Disease-susceptible (C3H) and -resistant (B6) immunocompetent and immunodeficient (C3H-scid and B6-rag1) mice were examined up to 10 weeks after inoculation with Helicobacter bilis (a prototype species of proven virulence). Infection was monitored...

Bostock M.G.; Kennett B.L.N., 1989: The effects of three-dimensional structure on crustally guided waves. Eos, Transactions, American Geophysical Union 70(15): 391-392

Ravin, N.V.; Mardanov, A.V.; Beletsky, A.V.; Kublanov, I.V.; Kolganova, T.V.; Lebedinsky, A.V.; Chernyh, N.A.; Bonch-Osmolovskaya, E.A.; Skryabin, K.G., 2009: Complete genome sequence of the anaerobic, protein-degrading hyperthermophilic crenarchaeon Desulfurococcus kamchatkensis. Desulfurococcus kamchatkensis is an anaerobic organotrophic hyperthermophilic crenarchaeon isolated from a terrestrial hot spring. Its genome consists of a single circular chromosome of 1,365,223 bp with no extrachromosomal elements. A total of 1,...

Erdmann, S.; Ricken, A.; Merkwitz, C.; Struman, I.; Castino, R.; Hummitzsch, K.; Gaunitz, F.; Isidoro, C.; Martial, J.; Spanel-Borowski, K., 2007: The expression of prolactin and its cathepsin D-mediated cleavage in the bovine corpus luteum vary with the estrous cycle. In the corpus luteum (CL), blood vessels develop, stabilize, and regress. This process depends on the ratio of pro-and antiangiogenic factors, which change during the ovarian cycle. The present study focuses on the possible roles of 23,000 (23K)...

Myasoedov N.A.; Butenko R.G.; Slepyan L.I., 1986: Cultivation of the biomass of panax ginseng tissue using a supporting substrate. The possibility of cultivating P. ginseng tissues on foam polyurethane for a long time was studied. Substrates with large or small pores were considered. Data are presented on the average weight of P. ginseng tissue cultivated on agar and on foam...

Fraceto, L.F.; Padula, C.; de Araujo, D.R., 2015: Nanoparticle carriers in medicinal chemistry and pharmaceutical sciences. Current Topics in Medicinal Chemistry 15(4): 280-281

Richard, D.I., 1968: The movement patterns of populations of red-winged blackbirds, Agelaius phoeniceus, in the western Lake Erie Basin. Dissertation Abstracts, 29B 1880-1881

Bondarenko S.K.; Kontrimavichus V.L., 1980: Dichoanotaenia multifilamenta new species cestoda dilepididae from the black turnstone arenaria melanocephala in alaska usa. D. multifilamenta sp. nov. from the Black Turnstone, A. melanocephala (Vigors), in Alaska is described. This cestode is distinguished from other Dichoanotaenia spp. Lopez-Neyra 1944 mainly by the structure of the cirrus and of the egg. [It is comp...

Fujimoto, S.; Araki, K.; Hamasato, S.; Noguchi, Y., 1992: CTL therapy as a rational specific immunotherapy for cancer. Artificial Organs 16(6): 645-646

Smith, Edward J., 1961: Buying versus renting a combine: a suggested basis for decision making. This analysis applies to a farm situation that is commonly found in the Mississippi Delta where oats and soyabeans are grown and where the soyabean acreage equals or to some extent exceeds that of oats. These farm operators can choose between hiri...