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A practical synthetic method for 3-(N,N-disubstituted carbamoyloxy)-methyl cephems without generating the DELTA-2-isomers

, : A practical synthetic method for 3-(N,N-disubstituted carbamoyloxy)-methyl cephems without generating the DELTA-2-isomers. Chemical and Pharmaceutical Bulletin (Tokyo) 43(6): 1031-1034

E1101, a new oral cephalosporin, has a (N,N-dimethylcarbamoyloxy)methyl group at the C-3 position of the cephem nucleus. The previous methods for manufacturing 3-(N,N-disubstituted carbamoyloxy)methyl cephems generate various amounts of intractable DELTA-2 isomers as by-products.


DOI: 10.1248/cpb.43.1031

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