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A survey of the humoral immune response of cancer patients to a panel of human tumor antigens

, : A survey of the humoral immune response of cancer patients to a panel of human tumor antigens. Journal Of Experimental Medicine. 187(8): 1349-1354, Il 20

Evidence is growing for both humoral and cellular immune recognition of human tumor antigens. Antibodies with specificity for antigens initially recognized by cytotoxic T lymphocytes (CTLs), e.g., MAGE and tyrosinase, have been detected in melanoma patient sera, and CTLs with specificity for NY-ESO-1, a cancer-testis (CT) antigen initially identified by autologous antibody, have recently been identified. To establish a screening system for the humoral response to autoimmunogenic tumor antigens, an enzyme-linked immunosorbent assay (ELISA) was developed using recombinant NY-ESO-1, MAGE-1, MAGE-3, SSX2, Melan-A, and tyrosinase proteins. A survey of sera from 234 cancer patients showed antibodies to NY-ESO-1 in 19 patients, to MAGE-1 in 3, to MAGE-3 in 2, and to SSX2 in 1 patient. No reactivity to these antigens was found in sera from 70 normal individuals. The frequency of NY-ESO-1 antibody was 9.4% in melanoma patients and 12.5% in ovarian cancer patients. Comparison of tumor NY-ESO-1 phenotype and NY-ESO-1 antibody response in 62 stage IV melanoma patients showed that all patients with NY-ESO-1+ antibody had NY-ESO-1+ tumors, and no patients with NY-ESO-1- tumors had NY-ESO-1 antibody. As the proportion of melanomas expressing NY-ESO-1 is 20-40% and only patients with NY-ESO-1+ tumors have antibody, this would suggest that a high percentage of patients with NY-ESO-1+ tumors develop an antibody response to NY-ESO-1.


PMID: 9547346

DOI: 10.1084/jem.187.8.1349

Other references

Stricker, H.; Salvetti, M., 1989: Rare vascular complications of behcet's disease. Vascular involvement in Behcet's disease is rare and may cause life-threatening complications. We report on 3 patients who presented with vascular problems in the course of the illness. (1) A 37-year-old woman suffered multiple pulmonary arte...

Coates M.E.; Henschel M.J.; Lyster R.L.J., 1968: Toxicity of cows milk to infant rabbits. National Institute for Research in Dairying Report (England) :

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Clavant, S.P.; Sastra, S.A.; Osicka, T.M.; Comper, W.D., 2005: The analysis and characterisation of immuno-unreactive urinary albumin in healthy volunteers. Objectives: To compare the analysis of different forms of intact albumin in urine from healthy volunteers. To determine contamination by common non-albumin proteins on HPLC analysis of urinary albumin and of purified immuno-unreactive albumin.Desi...

Cottenie, A.D.aese, A., 1978: Chemical characterization of muds. Annales de Gemblouxt Quarter 84(1): 25-34

Enger, P.Ø.; Svendsen, F.; Sommerfelt, K.; Wester, K., 2005: Shunt revisions in children--can they be avoided? Experiences from a population-based study. Shunt failure is by far the most frequent problem in children with shunts, and most of them will experience this condition at some point in their lives. In order to identify causes of shunt failure, and to compare multi-component and one-piece shu...

Trewyn, R.W.; Lehman, J.M.; Kerr, S.J., 1977: Cell transformation by exogenous methylated purines. Advances in Enzyme Regulation 16: 335-345