geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A yeast acetyl coenzyme A carboxylase mutant links very-long-chain fatty acid synthesis to the structure and function of the nuclear membrane-pore complex


, : A yeast acetyl coenzyme A carboxylase mutant links very-long-chain fatty acid synthesis to the structure and function of the nuclear membrane-pore complex. Molecular and Cellular Biology 16(12): 7161-7172

The conditional mRNA transport mutant of Saccharomyces cerevisiae, acc1-7-1 (mtr7-1), displays a unique alteration of the nuclear envelope. Unlike nucleoporin mutants and other RNA transport mutants, the intermembrane space expands, protuberances extend from the inner membrane into the intermembrane space, and vesicles accumulate in the intermembrane space. MTR7 is the same gene as ACC1, encoding acetyl coenzyme A (CoA) carboxylase (Acc1p), the rate-limiting enzyme of de novo fatty acid synthesis. Genetic and biochemical analyses of fatty acid synthesis mutants and acc1-7-1 indicate that the continued synthesis of malonyl-CoA, the enzymatic product of acetyl-CoA carboxylase, is required for an essential pathway which is independent from de novo synthesis of fatty acids. We provide evidence that synthesis of very-long-chain fatty acids (C26 atoms) is inhibited in acc1-7-1, suggesting that very-long-chain fatty acid synthesis is required to maintain a functional nuclear envelope.

US$19.90

PMID: 8943372

DOI: 10.1128/mcb.16.12.7161


Other references

Gumert William R., 1995: Third generation aerogravity system. International Union of Geodesy and Geophysics, General Assembly 21, Week B: 52

Amendola, L.; Corghi, A.; Cappuccio, M.; D.I.re, F., 2015: Two cases of Brown-Séquard syndrome in penetrating spinal cord injuries. Brown-Séquard syndrome due to a stab injuries is uncommon and results from a lesion in one half of the spinal cord. The role of surgery in the treatment of penetrating spinal injury often remain controversial. To discuss the current diagnostic an...

Vazquez, E., 2001: Remune trial stopped. Phase III trials of Remune, an AIDS vaccine based on inactivated HIV, stopped because no difference was found between patients taking the drug and those who did not. The manufacturer of the vaccine reported that adding highly active antiretroviral...

Fleming C.A., 1959: Buchia plicata Zittel and its allies, with a description of a new species, Buchia hochstetteri. Buchia plicata (Zittel) is illustrated by two topotypes from Tithonian (Jurassic) beds of the Puaroan stage at Waikato South Head, New Zealand; B. blanfordiana from the Himalayas is judged to be closely related. Specimens from Western Australia, r...

Inness, E.L.; Mansfield, A.; Lakhani, B.; Bayley, M.; McIlroy, W.E., 2015: Impaired reactive stepping among patients ready for discharge from inpatient stroke rehabilitation. Individuals with stroke are at increased risk for falls soon after hospital discharge. The ability to react to a balance perturbation, specifically with a rapid step, is critical to maintain balance and prevent falls. The purpose of the study was...

Lefebvre, J.S.; Lorenzo, E.C.; Masters, A.R.; Hopkins, J.W.; Eaton, S.M.; Smiley, S.T.; Haynes, L., 2016: Vaccine efficacy and T helper cell differentiation change with aging. Influenza and pneumonia are leading causes of death in elderly populations. With age, there is an increased inflammatory response and slower viral clearance during influenza infection which increases the risk of extended illness and mortality. Her...

Furlaneto-Maia, L.; Specian, A.Flavia.; Bizerra, F.Cesar.; de Oliveira, M.Tempesta.; Furlaneto, Márcia.Cristina., 2008: In vitro evaluation of putative virulence attributes of oral isolates of Candida spp. obtained from elderly healthy individuals. Identification of Candida isolates obtained from oral cavity of elderly healthy individuals revealed the predominance of non-albicans Candida species (88.9%) compared to Candida albicans (11%). CHROMagar Candida differential medium and PCR reveale...

Fenner, P.J.; Williamson, J.; Callanan, V.I.; Audley, I., 1986: Further understanding of, and a new treatment for, "Irukandji" (Carukia barnesi) stings. A brief analysis is presented of the large recorded numbers of swimmers who have been stung by the "Irukandji" (Carukia barnesi) jellyfish during the 1985-1986 summer season in north Queensland, and the results are discussed. Many of the...

D.R.os, A.M.; Persson, L., 2002: Beyond stability and predator-prey cycles. Ecological Society of America Annual Meeting Abstracts 87: 16

Kurazono, T.; Makino, S., 1997: Diversity of DNA sequences among enterohemorrhagic Escherichia coli O157:H7 detected by PCR-based DNA fingerprinting. A random amplified polymorphic DNA(RAPD) fingerprinting method has been developed to differentiate Enterohemorrhagic Escherichia coli(EHEC) O157:H7 isolates. This method uses an oligonucleotide of arbitrarily chosen sequence to prime DNA synthesis...