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ATP sensitive potassium channels: Potential drug targets in neuropsychopharmacology


, : ATP sensitive potassium channels: Potential drug targets in neuropsychopharmacology. Progress in Neuro Psychopharmacology and Biological Psychiatry 18(7): 1093-1102

1. K channels are a diverse and ubiquitous class of proteins that regulate a number of biological functions. 2. Ligands for the study of a variety of K channels are available. These include "openers" and antagonists for the ATP sensitive K channel and peptide toxins such as apamin and charybdotoxin that block other subtypes. 3. Antagonists of the ATP sensitive K channel are useful in the treatment of type II diabetes while "openers" of this channel are being tested in asthma and cardiovascular disease. 4. Intracerebroventricular administration of K channel "openers" block experimentally induced seizures in rodents through a hyperpolarization of neurons. K channel openers may also be useful in the treatment of neurodegenerative diseases, pain and cerebral ischemia. 5. A key to the development of psychopharmacological agents to modify brain K channel function is CNS selectivity. The promise of the ATP sensitive K channel openers suggests a bright future for this mechanism.

US$19.90

PMID: 7846282

DOI: 10.1016/0278-5846(94)90113-9


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