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Acute t-PA releasing effect of supersulphated low molecular weight heparins


, : Acute t-PA releasing effect of supersulphated low molecular weight heparins. Fibrinolysis. 8(suppl. 2): 75-77

Different supersulphated low molecular weight heparins (SSLMWH, Lab. Code: SSH 11, SSH 13, SSH 14), isolated after controlled depolymerisation and contemporary sulphatation of pig mucosal unfractionated heparin (Italian Patent 22504 A/89), were tested for their in vitro and in vivo t-PA releasing activity. The different SSH preparations developed proribrinolytic activity on the basis of tissue-type plasminogen activator (t-PA) release during perfusion of isolated pig ear and after i.v.-application in rats. The acute t-PA release induced by SSH 11, 13 and 14 was in a higher range in the isolated perfused pig ear model than that induced by unfractionated heparin at a concentration of 50 mu-g/ml perfusion solution. The highest acute increase of t-PA was caused by SSH 14 with 200%. SSH 14 was dose-dependently tested for acute t-PA release in rats after intravenous administration of 1.0, 2.5, 5.0 and 10.0 mg SSH/kg body weight. The maximum net increase of t-PA release was reached 1 to 5 min after i.v. application of SSH 14. After the administration of 5 or 10 mg/kg, resp., SSH 14 produced an increase in maximum t-PA release between 7 and 8 I.U./ml plasma. The t-PA releasing effect of SSLMWH might contribute to the antithrombotic effect of SSH 14.

US$19.90

DOI: 10.1016/0268-9499(94)90252-6


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