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Adenosine A-1 receptor blockade selectively potentiates the motor effects induced by dopamine D-1 receptor stimulation in rodents


, : Adenosine A-1 receptor blockade selectively potentiates the motor effects induced by dopamine D-1 receptor stimulation in rodents. Neuroscience Letters. 218(3): 209-213

An antagonistic interaction between adenosine A-1 and dopamine D-1 receptors has previously been found in the basal ganglia. However, direct evidence for a selective adenosine A-1 antagonist-induced potentiation of dopamine D-1-mediated motor activation is lacking. The systemic administration of the adenosine A-1 antagonist 8-cyclopentyl-1,3-dimethylxanthine significantly potentiated the motor activating properties of the systemically administered dopamine D-1 agonist SKF 38393 in both reserpinized mice and unilaterally 6-hydroxy-dopamine-lesioned rats. However, 8-cyclopentyl-1,3-dimethylxanthine did not modify the motor effects of the dopamine D-2 agonist quinpirole. The present work shows that an antagonistic interaction between adenosine A-1 and dopamine D-1 receptors may be involved in the motor activating effects of adenosine antagonists, like caffeine.

US$19.90

PMID: 8945765

DOI: 10.1016/s0304-3940(96)13143-8


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