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Altered RNA turnover in carcinogenesis. The diagnostic potential of modified base excretion

, : Altered RNA turnover in carcinogenesis. The diagnostic potential of modified base excretion. Molecular and Chemical Neuropathology 21(2-3): 353-368

Excretion of urinary modified nucleosides is frequently elevated in patients with oncogenic disease. Increases of urinary pseudouridine excretion are now demonstrated in patients with a variety of brain tumors. The potential use of urinary modified base excretion as a cancer marker is discussed and possible sources of the elevated nucleosides are detailed. The specific steps in RNA metabolism that result in increased levels of RNA nucleoside excretion are poorly understood. This knowledge will be necessary to understand the molecular mechanism and the clinical significance of urinary nucleoside excretion in treatment and diagnosis of oncogenic disease.


PMID: 7522008

DOI: 10.1007/BF02815361

Other references

Gillet, M.; Huguet, L.; Mourguet, A.; Posny, P.; Roy, A. le; Breisch, H., 1980: Is it possible to conciliate grazing and full use of herbage grasses? A new approach to an old problem. III. Some grazing systems for two varieties studied at Poitou. The problem of spring rotational grazing when grasses are at a vulnerable stage is briefly discussed and 2 systems based on only 2 complementary spp. are proposed for the Poitou region which is subject to summer drought. One system based on semi-l...

Yttergren, L., 1996: Stockholm and the rise of modern sports, 1860-98. The transformation process by which sport had become an organized and comprehensive social movement in Stockholm, Sweden, is outlined. In the early association structure, physical activity-oriented and recreational sports stood in the foreground a...

Balakrishna S.; Ramana Rao A.V., 1974: Geology and structure of Veldurti-Gani area, Kurnool District, Andhra Pradesh. Geophysical Research Bulletin 12(4): 183-198

Anonymous, 1916: County Society Activity. California State Journal of Medicine 14(7): 263-264

Takada, K.; Sugita, S.; Ikeuchi, R.; Okuda, N.; Fujinami, T., 1993: Body composition measurement by electrical bio-impedance method to establish the effect of daily physical training in adolescents. As part of an ongoing study on the effect of daily physical training on adolescents, body composition (percentage fat) was measured using the electrical bio-impedance method in a sample of Japanese students aged 15 years (77 sedentary males, 137 a...

Bernhardson, B-Marie.; Tishelman, C.; Rutqvist, L.Erik., 2007: Chemosensory changes experienced by patients undergoing cancer chemotherapy: a qualitative interview study. Few studies explore patients' experiences of smell and taste changes during cytotoxic chemotherapy. Issues, such as how such changes impact daily life, their consequences, and how patients respond to chemotherapy-induced chemosensory changes,...

Brown, R.Jr, 1988: Barbados. Global review of agricultural policies: 7

Hering, M., 1919: On the Biology and systematic Position of S. temperatella. Scythris temperatella, Led., for which the author proposes the new generic name Syringopais, is a grain pest in Asia Minor. The egg and larva are described. The larva mines the leaves of barley, wheat, and probably other grasses. The infested leav...

Barbashin, I.A.; Makarov, V.T., 1977: Hydrops in abeyrant gallbladder. Khirurgiia: 131-131

Vaitkus, P.T., 1995: Limitations of primary angioplasty in acute myocardial infarction. British Heart Journal 73(5): 409-410