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Animal models relevant to human epilepsies

, : Animal models relevant to human epilepsies. Italian Journal Of Neurological Sciences. 16(1-2): 5-8

Animal studies have significantly contributed to our understanding of epileptogenesis and action mechanisms of antiepileptic drugs. The relevance of animal models to human epilepsies depend on how faithfully they reproduce the clinical and EEG features of human forms. In principle the definition of animal model of epilepsies should be reserved to animals presenting with recurrent seizures, either spontaneous of experimentally induced, persisting over time. Therefore acute experimental procedures designed to induce seizure andin vitro preparations should be referred to as models of seizures and models of epileptogenic mechanisms respectively rather models of epilepsies. The adequacy of a given animal model to study basic mechanisms of epilepsies and/or drug efficacy depend on the type of information that the investigator want to draw from it.


PMID: 7642352

DOI: 10.1007/bf02229068

Other references

Muller F.; Ohmura A.; Braithwaite R., 1973: The North Water Project; Canada, Greenland, Arctic region. Geographica Helvetica 28(2): 111-117

Meredith, E.L.; Mainolfi, N.; Poor, S.; Qiu, Y.; Miranda, K.; Powers, J.; Liu, D.; Ma, F.; Solovay, C.; Rao, C.; Johnson, L.; Ji, N.; Artman, G.; Hardegger, L.; Hanks, S.; Shen, S.; Woolfenden, A.; Fassbender, E.; Sivak, J.M.; Zhang, Y.; Long, D.; Cepeda, R.; Liu, F.; Hosagrahara, V.P.; Lee, W.; Tarsa, P.; Anderson, K.; Elliott, J.; Jaffee, B., 2016: Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration. The benefit of intravitreal anti-VEGF therapy in treating wet age-related macular degeneration (AMD) is well established. Identification of VEGFR-2 inhibitors with optimal ADME properties for an ocular indication provides opportunities for dosing...

Pundziute-Lyckå, A.; Persson, L-Ake.; Cedermark, G.; Jansson-Roth, A.; Nilsson, U.; Westin, V.; Dahlquist, G., 2004: Diet, growth, and the risk for type 1 diabetes in childhood: a matched case-referent study. To study the association between type 1 diabetes risk and previous intake of energy, accounting for body size and previous intake of nutrients and foods, accounting for the energy intake. We conducted an incident population-based case-referent stu...

Khan, M.; Bouet, G.; Tanveer, R.; Ahmed, R., 1999: Stability constants of thiocyanato complexes of cobalt , nickel and copper in methanol. A spectrophotometric study of cobalt(II), nickel(II) and copper(II) thiocyanato complexes was carried out in methanol at 25degreeC and at a constant ionic strength of 1 M. Under the experimental conditions, two mononuclear complexes are identified...

Welihinda, A.A.; Tirasophon, W.; Kaufman, R.J., 2000: The transcriptional co-activator ADA5 is required for HAC1 mRNA processing in vivo. Accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates signaling pathways to induce transcription of a number of genes encoding ER protein chaperones and-folding catalysts. In Saccharomyces cerevisiae this transcriptional in...

Konno Enzo, 1960: Schizoneura manchuriensis Konno and its fructification (Manchurostachys n. gen.) from the Gigantopteris-nicotianaefolia-bearing Formation in Penchihu coal-field, northeastern China. The remains of Schizoneura manchuriensis and its fructification, here assigned to the new genus Manchurostachys, from Permian deposits of the Penchihu coal field, Manchuria, closely resemble those of S. gondwanensis, an important member of the Glo...

Vala, M.C.; Sturchio, G.M., 1993: Radiation safety training for non-radiation workers. Health Physics 64(SUPPL 6): S82

Robertson, D.W.; Tsuchiya, T.; Haus, T.E., 1971: Genetic stocks of mapped genes available at Genetic Stock Center, Fort Collins, Colorado. Barley lines available are listed, the gene symbols, the character conditioned by each of the genes and the variety or origin of the gene being given. The genes are listed under the chromosome in which they were mapped.

Vieira, M.C.F.; Moreno, S.N.J., 2000: Mobilization of intracellular calcium upon attachment of Toxoplasma gondii tachyzoites to human fibroblasts is required for invasion. It was shown that during the interaction of Toxoplasma gondii tachyzoites with fibroblasts an increase in cytosolic Ca2+ occurs in the parasite. Buffering increases in cytosolic Ca2+ of tachyzoites by intracellular Ca2+ chelators resulted in an in...

Paget, M.; Vincent, G., 1971: Speech delivered by professor Marcel Paget at obsequies of professor Georges Vincent. Journal des Sciences Medicales de Lille 89(1): 1-4