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Ankle muscle activity before and after botulinum toxin therapy for lower limb extensor spasticity in chronic hemiparetic patients


, : Ankle muscle activity before and after botulinum toxin therapy for lower limb extensor spasticity in chronic hemiparetic patients. Stroke 27(3): 455-460

Background and Purpose: Recent studies have been made of the novel treatment of lower limb spasticity after stroke with botulinum toxin A, and the results were based mostly on the clinical assessment made before and after treatment. This study investigated the effects of the toxin on ankle muscle activity during gait in patients with severe extensor spasticity. The questions posed were whether the toxin particularly diminishes the so-called premature muscle activity as a major cause of equinovarus deformity and whether different types of altered motor control allow a prediction of the outcome of the treatment. Methods: In 12 chronic hemiparetic outpatients with pronounced lower limb spasticity, we injected 400 U botulinum toxin A into the soleus and tibialis posterior muscles and in both heads of the gastrocnemius muscles. Ankle spasticity and complex gait analysis including kinematic electromyography (EMG) of the soleus and tibialis muscles were assessed before treatment and 4 weeks after the injection. Results: Nine patients profited with a reduction of spasticity, improved gait ability, and a more normal temporal pattern of muscle activity with a prominent reduction of the premature activity of the plantar flexors. Eight patients exhibited a qualitative pattern (type I) corresponding to an increased stretch-reflex excitability. Three patients did not profit: their muscle tone, gait ability, and muscle activation remained stable or even deteriorated. Conclusions: This study further supports the beneficial effects of botulinum toxin in the treatment of lower limb extensor spasticity. A correlation was observed between the clinical reduction of muscle tone, functional gait parameters, and a more normal EMG pattern with a predominant reduction of the premature activity of the plantar flexors. The qualitative type of EMG pattern corresponding to an increased stretch-reflex excitability (type I) was a positive predictor for the outcome.

US$29.90

PMID: 8610313


Other references

Snyder, B.J.; Lohman, T.G.; Going, S.B.; Davis, R.L., 1997: Effects of hormone replacement therapy on muscle specific torque and strength gains. Medicine & Science in Sports & Exercise 29(5 SUPPL ): S93

Brunetti, F., 1958: Attempted evaluation of alveolar permeability by diapulmonary administration of odoriferous substances; experiments of Bonelli and Semeria. Minerva Otorinolaringologica 8(10): 379-381

Farahvash, M.J.; Janney, C.G.; Salimi, Z.; Majdi, G.; Bacon, B.R., 1994: Jejunized colon: a rare complication of carcinoid tumor. A 23-yr-old female with a history of dyspnea, palpitation, productive cough, occasional hemoptysis, intermittent diarrhea, and abdominal pain was found to have metastatic carcinoid tumor and a "jejunized colon." Carcinoid tumors are rela...

Morel A., 1983: Erosion and sedimentation in the Air Massif, southern Sahara; paleoclimatic interpretation of the median terrace. Mineral Resources Report (Botswana) 13(2): 111-118

Muggeo M.; Ginsberg B.H.; Roth J.; D.M.yts P.; Falkmer S., 1977: The insulin receptor and insulin of the atlantic hagfish extraordinary conservation of binding specificity and negative cooperativity in a very primitive vertebrate. Diabetes 26(SUPPL 1): 353

Lupinacci, R.M.; Vallet, C.; Parc, Y.; Chafai, N.; Tiret, E., 2011: Treatment of fistula-in-ano with the Surgisis(®) AFP(TM) anal fistula plug. Closure of the fistula tract with an anal fistula plug has been reported to provide success rates as high as 80%. The purpose of this study was to evaluate our results with this new method. From June 2006 to September 2007, an anal fistula plug wa...

Teeter, R.G.; Belay, T.; Cason, J.J., 1996: Turkey and broiler production can be optimized during heat stress. This article examines research on turkey and broiler production during heat stress. Ration composition, in particular electrolytes, energy, protein and methionine, is discussed along with the use of growth promoters.

Minckley, C.O.; Klaassen, H.E., 1969: Life history of the plains killifish, Fundulus kansae (Garman), in the Smoky Hill River, Kansas. Transactions of the American Fisheries Society, 98: 460-465

Berg N.H., 1988: Mountain top riming at sites in california and nevada usa. Icing at locations near Lake Tahoe and in northern California appears to be soft or hard rime. At one site during three recent winters, and at six other locations during the winter of 1986/87, riming was common, occurring on average during 38% of...

Strand Carl; Gastil Gordon; Marshall Monte, 1981: Determination of epicenter and magnitude for the Southern California-Baja California earthquake of February 23, 1892. Abstracts with Programs - Geological Society of America 13(2): 108