+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Antibacterial activity of benzydamine and antibiotic-benzydamine combinations against multifold resistant clinical isolates

, : Antibacterial activity of benzydamine and antibiotic-benzydamine combinations against multifold resistant clinical isolates. Arzneimittel-Forschung 46(3): 320-323

The bactericidal activity of 0.1% benzydamine (CAS 642-72-8, BD). a non-steroidal anti-inflammatory agent was evaluated by the viable count technique against 12 multifold resistant clinical isolates. An efficient rapid activity was obtained irrespective of the antibiotic resistance pattern. Combinations of 0.1% BD and ampicillin, chloramphenicol or tetracycline exerted synergistic bactericidal activity against antibiotic resistant Pseudomonas aeruginosa and Staphylococcus aureus isolates. Using the chessboard technique, out of 114 BD-antibiotic bacteriostatic combinations, 19 were partially synergistic and the remaining were indifferent. The effect of subinhibitory concentrations of BD-ampicillin, BD-chloramphenicol and BD-tetracycline on the growth of the test organisms revealed significant synergism, especially with tetracycline combinations, most likely due to enhanced uptake of the antibiotic by the organisms in the presence of BD.


PMID: 8901158

Other references

Granfors, K.; Jalkanen, S.; Toivanen, P.; Koski, J.; Lindberg, A.A., 1992: Bacterial lipopolysaccharide in synovial fluid cells in Shigella triggered reactive arthritis. Journal of Rheumatology 19(3): 500-500

McLachlan, D., 1958: Crystal Structure And Information Theory. Proceedings of the National Academy of Sciences of the United States of America 44(9): 948-956

Cheung, E.; Schwabish, M.A.; Kraus, W.Lee, 2003: Chromatin exposes intrinsic differences in the transcriptional activities of estrogen receptors a and b. The EMBO Journal 22(3): 0-11

Lawalree A., 1971: The improverishment of the belgian flora. Bulletin du Jardin Botanique National de Belgique 41(1): 167-171

Fedorov, P.N.; Ryabchuk, G.N.; Zverev, A.V., 1997: Comparison of hydride generation and graphite furnace atomic absorption spectrometry for the determination of arsenic in food. Hydride generation (HG) and graphite furnace atomic absorption spectroscopy for determination of arsenic in various foodstuffs are compared. Two methods of sample pre-treatment, wet ashing and pressurized decomposition in an autoclave, are discuss...

Parupia, M.F.H.; Gilmartin, R.C.; Pickert, C.B., 1997: Seasonal variation in the incidence of seizures in hospitalized children A retrospective study. Epilepsia 38(SUPPL 8): 249-250

Zhao, P.; Xue, J.; Gu, X-Qun.; Haddad, G.G.; Xia, Y., 2005: Intermittent hypoxia modulates Na+ channel expression in developing mouse brain. Because our previous work showed that intermittent hypoxia alters neuronal excitability and Na+ current density, we examined in this work the effect of intermittent hypoxia on Na+ channel subtypes using H-3-saxitoxin (H-3-STX) autoradiography and...

Horsburgh, M.P.; Bycroft, J.J.; Goodyear-Smith, F.A.; Roy, D.E.; Mahony, F.M.; Donnell, E.Cj.; Miller, D.J., 2011: The Flinders Program™ of chronic condition self-management in New Zealand: survey findings. The Flinders Program™ of Chronic Condition Self-Management in New Zealand (NZ) has been given focus as a useful and appropriate approach for self-management support and improvement of long-term condition management. To determine the use of the F...

Semmelhack M.F.; Gallagher J.; Cohen D., 1990: Bioreductive alkylation as a trigger for toxic effects of dynemicin. The endiyne derivative, dynemicin, is postulated to undergo bioreductive cis ring opening of a benzylic epoxide and activate the endiyne unit for Bergman rearrangement to an arene-1,4-diyl.

Rosenberger P.B., 1969: Visual stimulus generalization with parietal occipital lobe lesions abstract human. Neurology 19(3): 293