+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma

, : Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Research 56(20): 4625-4629

Angiogenesis is a key process in tumor growth and metastasis and is a major independent prognostic factor in breast cancer. A range of cytokines stimulate the tumor neovasculature, and tumor-associated macrophages have been shown recently to produce several important angiogenic factors. We have quantified macrophage infiltration using Chalkley count morphometry in a series of invasive breast carcinomas to investigate the relationship between tumor-associated macrophage infiltration and tumor angiogenesis, and prognosis. There was a significant positive correlation between high vascular grade and increased macrophage index (P = 0.03), and a strong relationship was observed between increased macrophage counts and reduced relapse-free survival (P = 0.006) and reduced overall survival (P = 0.004) as an independent prognostic variable. These data indicate a role for macrophages in angiogenesis and prognosis in breast cancer and that this cell type may represent an important target for immunoinhibitory therapy in breast cancer.


PMID: 8840975

Other references

Berger, K.; Hense, H.W.; Rothdach, A.; Weltermann, B.; Keil, U., 2000: A single question about prior stroke versus a stroke questionnaire to assess stroke prevalence in populations. Background: False-positive and false-negative answers to screening questions influence prevalence and incidence estimations for stroke in population studies. Despite frequent use in screening, only a few studies have examined causes and influence...

Cheng, J.; D.T.ledo, F.G.S.; Thompson, M.; Dousa, T.P., 1998: Retinoids and 1,25- 2-vitamin D3 upregulated ADP-ribosyl and inhibit mitogenesis in rat vascular smooth muscle cells. Journal of the American Society of Nephrology 9(PROGRAM AND ABSTR ISSUE): 420A, Sept

Higuchi, I.; Nonaka, I.; Usuki, F.; Ishiura, S.; Sugita, H., 1987: Acid maltase deficiency in the Japanese quail; early morphological event in skeletal muscle. The skeletal muscle of Japanese quails with acid maltase deficiency (AMD) was studied morphologically at various developmental stages, from the 16th embryonal day up to 3 months after hatching. Membrane-bound glycogen particles began to appear in...

Contreras, Marcella, 1994: Antenatal tests in the diagnosis and assessment of severity of haemolytic disease of the fetus and newborn. Vox Sanguinis 67(SUPPL 3): 207-210

Lysenko, T.D., 1947: Why bourgeois science is against the work of Soviet scientists. The author expounds his theory that intraspecific competition does not occur, taking as his example the higher yields obtained by planting kok-saghyz in clusters (cf. Plant Breeding Abstracts, Vol. XVII, Abst. 585). It is suggested that this metho...

Breda, G.; Graziotti, P.; Calabro, A.; Pegoraro, V.; Lembo, A., 1986: Reversed nesbit operation for peyronie's disease a 17 case experience. During the past two years 17 consecutive patients with curved penis due to Peyronie's were submitted to surgical correction at the Institute of Urologyof Padua University [Italy]. The surgical approach was a modification of the technique prop...

Priester, J.H.; Olson, S.G.; Webb, S.M.; Neu, M.P.; Hersman, L.E.; Holden, P.A., 2006: Enhanced exopolymer production and chromium stabilization in Pseudomonas putida unsaturated biofilms. Chromium-contaminated soils threaten surface and groundwater quality at many industrial sites. In vadose zones, indigenous bacteria can reduce Cr(VI) to Cr(III), but the subsequent fate of Cr(III) and the roles of bacterial biofilms are relatively...

Bakhle, Y.S., 1979: Action of prostaglandin dehydrogenase inhibitors on prostaglandin uptake in rat isolated lung. 1. The effects of some inhibitors of 15-hydroxy-prostaglandin dehydrogenase (PGDH) have been studied on the inactivation of prostaglandin E2 (PGE2) and 16, 16-dimethyl PGE2 in rat isolated lung. 2. Bioassay was used to show that the inactivation o...

Zhang ChuLong;, 2003: Advances on molecular phylogeny and classification of the genus Trichoderma and its related teleomorphs. This paper reviews the recent advances on the molecular phylogeny and classification of the genus Trichoderma.

Russo, P., 1980: A trial to characterize Chlamydia strains of bovine origin. Bulletin des GTV Groupements techniques veterinaires Dossiers techniques veterinaires: (3) 27-30