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Augmentation of the chemotherapeutic effectiveness of UFT, a combination of tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) with uracil, by oral l-leucovorin

, : Augmentation of the chemotherapeutic effectiveness of UFT, a combination of tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) with uracil, by oral l-leucovorin. Anticancer Research 17(1A): 157-164

UFT, combination of tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) with uracil, is widely used as an anti-neoplastic agent in Japan. We evaluated the anti-tumor efficacy of the combined modality of UFT with oral l-leucovorin. The augmentation of anti-tumor activity of UFT by coadministration of l-leucovorin was observed over a dose of 1.85 mg/kg (5.55 mg/m-2) and was significant at a dose of 5.56 mg/kg (16 7 mg/m-2).


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