geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Bacterial translocation: a potential source for infection in acute pancreatitis


, : Bacterial translocation: a potential source for infection in acute pancreatitis. Pancreas 8(5): 551-558

Infections from enteric bacteria are a major cause of morbidity and mortality during acute pancreatitis (AP), but the pathways by which these organisms reach distant organs remains speculative. Experiments were conducted to determine if bacterial translocation could be a mechanism for infection during this disease. AP was induced in Lewis rats by i.v. infusion of caerulein (experiment I) or ligation of the head of the pancreas (experiment II). In a third experiment, rats were gavaged with 1 times 10-8 14C-radiolabeled Escherichia coli and pancreatitis was induced with caerulein. Results in all three experiments showed that AP increased the number of viable bacteria recovered in peritoneal fluid, mesenteric lymph nodes (MLN), liver, lungs, and pancreas. Radionuclide counting indicated that AP enhanced the gut permeability to 14C E. coli. To estimate the impact of AP on the magnitude of translocation and on the ability of the host to clear bacteria, the nuclide and colony-forming units (CFU) ratios were calculated between animals with and without AP. Blood, peritoneal fluid, and MLN had the highest nuclide ratio. During AP, these tissues may be the principal routes for bacterial spreading from the gut lumen. Peritoneal fluid, pancreas, and lung were the tissues with the highest CFU ratio. Bacterial killing ability of these tissues is likely impaired during AP.

US$29.90

PMID: 8302791


Other references

Winkler, H., 1947: Grazing on different soils. 6. The Flahult moor grazings. The management, manurial treatment and quality of moor grazings of different types is discussed. The advantages of such pastures lie in the uniformity of growth, except perhaps about midsummer, although the yield is relatively low, and in their re...

Kefaloyianni, E.; Gaitanaki, C.; Beis, I., 2006: ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts. Skeletal muscle is highly adapted to respond to oxidative imbalances, since it is continuously subjected to an increased production of reactive oxygen species (ROS) during exercise. Oxidative stress, however, has been associated with skeletal musc...

Nevin, R.L.; Means, G.E., 2009: Pain and discomfort in deployed helicopter aviators wearing body armor. In early 2007, U.S. Army helicopter aviators deployed to Afghanistan complained of increased pain frequency during flight. The aviators attributed this pain to body armor, which had not been worn prior to deployment. This study was conducted to in...

Mester, L., 1989: Experience of setting of local fuel norms for agricultural machinery. Examinations of fuel use by cooperative farms in Hungary have led to the construction of energy norms. These can be used as a means of identifying the need for greater fuel consumption and as a basis for farm comparisons.

Ramirez-Zamora, A.; Okun, M.S., 2016: Deep brain stimulation for the treatment of uncommon tremor syndromes. Deep brain stimulation (DBS) has become a standard therapy for the treatment of select cases of medication refractory essential tremor and Parkinson's disease however the effectiveness and long-term outcomes of DBS in other uncommon and compl...

Rodríguez, D.; Chakraborty, S.; Warnick, E.; Crane, S.; Gao, Z-Guo.; O'Connor, R.; Jacobson, K.A.; Carlsson, J., 2016: Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists. NlmCategory="UNASSIGNED">Small molecule screening libraries cover only a small fraction of the astronomical number of possible drug-like compounds, limiting the success of ligand discovery efforts. Computational screening of virtual l...

Mackay-Smith, M., 1980: Facing a fracture. What are the odds for recovery?. Equus (30) 32-38

Kaplow, L.S., 1984: The histochemist's phantom image analyser. Histochemical Journal 16(6): 617-622

Moreira, X.; Abdala-Roberts, L.; Zas, R.; Merlo, E.; Lombardero, M.J.; Sampedro, L.; Mooney, K.A., 2016: Masting behaviour in a Mediterranean pine tree alters seed predator selection on reproductive output. NlmCategory="UNASSIGNED">Context-dependency in species interactions is widespread and can produce concomitant patterns of context-dependent selection. Masting (synchronous production of large seed crops at irregular intervals by a pla...

Amhad, I.; Siddiqui, MKH.; Ray, PK., 1987: Pesticide burden on some insects of economic importance in Lucknow India Pesticide burden on some insects of economic importance in Lucknow India. Environmental Monitoring and Assessment, 91: 25-28