geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Basal and stress-induced corticosterone secretion is decreased by lesion of mesencephalic dopaminergic neurons


, : Basal and stress-induced corticosterone secretion is decreased by lesion of mesencephalic dopaminergic neurons. Brain Research. 622(1-2): 311-314

There is evidence that certain psychopathological conditions are accompanied by a dysfunction in both the hypothalamo-pituitary-adrenal axis and dopaminergic systems, although the relationship between these two systems is as yet unclear. In the present study we investigated the effect of a specific lesion of dopamine mesencephalic neurons (Ventral Tegmental Area) on basal and stress-induced corticosterone secretion. Three weeks after injection of 6-OHDA, there was a depletion in dopamine in the frontal cortex and in the ventral and dorsal striatum, whereas norepinephrine and serotonin levels were unchanged. The dopamine-lesioned rats exhibited a lower basal and stress-induced corticosterone secretion than the sham-lesioned animals. The results indicate that the dopaminergic system may have a stimulatory influence on the hypothalamo-pituitary-adrenal axis.

US$19.90

PMID: 8242373

DOI: 10.1016/0006-8993(93)90836-c


Other references

Brandes, S.; Brandes, D., 1996: Flora and vegetation of villages in the western part of Sachsen-Anhalt. Flora and vegetation in 15 villages in Sachsen-Anhalt are investigated. Altogether 569 vascular plant species are found. 189 of them occur with high frequency, that means in 61% or more of the investigated villages. The most important structure or...

Kment A.; Strauer B.E., 1981: Influence of prenalterol on central and coronary hemodynamics. Naunyn-Schmiedeberg's Archives of Pharmacology 316(SUPPL): R77

Stone J.; Hutcheon I.D.; Epstein Samuel; Wasserburg G.J., 1991: Correlated Si isotope anomalies and large (super 13) C enrichments in a family of exotic SiC grains. Earth and Planetary Science Letters 107(3-4): 570-581

Vassallo, R.; Wilson, D.J., 1999: 81-year-old man with unusual spells. Mayo Clinic Proceedings 74(4): 415-418

Stuckey Jasper Leonidas, 1937: Volcanic rocks in the eastern Piedmont of North Carolina. The Journal of the Elisha Mitchell Scientific Society 53(2): 227-228

Small, C.V.J., 1965: Soil problems for banana cultivation in Surinam. The heavy clay soils reclaimed from swamps in the coastal plain and often used for banana production possess inadequate structure and depth; those having been under rice have bad physical properties and are difficult to improve for banana cultivat...

Hofsvang, L., 1976: Development of anthocoris sibiricus heteroptera anthocoridae at constant and fluctuating temperatures with the green peach aphid myzus persicae as prey. Time of development of A. sibiricus was studied at temperatures fluctuating from 8.degree.-28.degree. C, and at constant temperatures of 8.degree., 18.degree. and 28.degree. C. M. persicae was used as prey. Development at fluctuating temperature w...

Autret, A., 1980: Present status of neurology in 1980. La Revue du Praticien 30(59): 4117-20, 4125-8

Zhuang, Y-Long.; Ren, G-Jie.; Tian, K-Li.; Li, X-Ye.; Zhu, Y-Bao.; Liu, J-Ling.; Si, G-Ling.; Li, P.; Zhang, Y.; Wang, L.; Zhang, W-Jing.; Wang, D-Jian.; Zhu, C-Fu., 2012: Human leukocyte antigen-C and killer cell immunoglobulin-like receptor gene polymorphisms among patients with syphilis in a Chinese Han population. Syphilis is a sexually transmitted infection caused by the Treponema pallidum subspecies pallidum spirochete bacterium. The killer cell immunoglobulin-like receptors (KIR), interacting with human leukocyte antigens (HLA), regulate the activations...

Hong, C-Soo.; Saint-Jeannet, J-Pierre., 2007: The activity of Pax3 and Zic1 regulates three distinct cell fates at the neural plate border. In Xenopus, the neural plate border gives rise to at least three cell populations: the neural crest, the preplacodal ectoderm, and the hatching gland. To understand the molecular mechanisms that regulate the formation of these lineages, we have a...