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Bayesian individualization via sampling-based methods


, : Bayesian individualization via sampling-based methods. Journal Of Pharmacokinetics & Biopharmaceutics. 24(1): 103-131

We consider the situation where we wish to adjust the dosage regimen of a patient based on (in general) sparse concentration measurements taken on-line. A Bayesian decision theory approach is taken which requires the specification of an appropriate prior distribution and loss function. A simple method for obtaining samples from the posterior distribution of the pharmacokinetic parameters of the patient is described. In general, these samples are used to obtain a Monte Carlo estimate of the expected loss which is then minimized with respect to the dosage regimen. Some special cases which yield analytic solutions are described. When the prior distribution is based on a population analysis then a method of accounting for the uncertainty in the population parameters is described. Two simulation studies showing how the methods work in practice are presented.

US$19.90

PMID: 8827585

DOI: 10.1007/bf02353512


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Bush, W.J.; Gregg, D.K.; Smith, E.A.; Mcbride, C.B., 1965: Some interactions between individual differences and modes of instruction. This study explored the hypothesis that there is a relationship between patterns of learning ability and the amount learned in different instructional conditions. Scores for each of 44 subjects were obtained on the Reading Vocabulary and the Mathe...

Zadadaeva, R.G.yzlov, A., 1978: Centalized delivery management and accounting problems. Sovetskaia torgovlia: 30-31

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Carranza, F.A.; Newman, M.G., 1980: Current concepts about dental plaque. Revista de la Asociacion Odontologica Argentina 68(5): 293-294

Godowicz B.; Musialek B., 1990: Differential response to cadmium chloride of female mice from small populations mated with maximal avoidance of inbreeding. The previously found cadmium-sensitivity of males belonging to two stocks A and C, was an inspiration for experiments with females from the same stocks. Administration of a single dose of cadmium chloride to females from two stocks A and C, allowe...

Melcher, U.; Lartey, R.T.; Pennington, R.E., 1992: Isolate-specific synergy in symptom production between a caulimo virus and a tobamovirus. Phytopathology 82(10): 1173-1174

Shrestha, J.N.B.; Grunder, A.A.; Dickie, J.W., 2004: Evaluation of Pilgrim, Hungarian, Chinese, Synthetic and Embden strains of geese and their crosses for body weight. The Pilgrim, Hungarian, Chinese, Selected Chinese, Synthetic (developed from Pilgrim, Chinese and Hungarian), Selected Synthetic, Large Embden and Small Embden strains of geese raised from 1980 to 1988 at the Greenbelt farm of the Centre for Food...

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Rowlett, K.; Simkiss, K., 1989: Respiratory gases and acid-base balance in shell-less avian embryos. 1. The PCO2 and PO2 levels of oxygenated and deoxygenated embryonic blood were measured in normal and shell-less cultured embryos. 2. Embryos in shell-less culture were both hypoxic and hypocapnic, suggesting that wetting the respiratory membranes...

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