geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

CCK-8 activates hepatic vagal C-fiber afferents


, : CCK-8 activates hepatic vagal C-fiber afferents. Brain Research. 776(1-2): 189-194,. 21

Intravenous administration of 2 mug/kg CCK-8 increased the single unit activity of 54% of hepatic vagal afferent fibers. Conduction velocity tests indicated that all of these units were C fibers. The increase in hepatic vagal activity produced by CCK-8 was significantly reduced by i.v. administration of 200 mug/kg of the CCKA receptor antagonist devazepide. Control comparisons indicated that this reduction was not an artifact of tachyphylaxis resulting from repeated administration of CCK-8. Further, the inability of pretreatment with atropine and hexamethonium to reduce the increases in hepatic vagal activity produced by CCK-8 suggests that the latter effect was not secondary to changes in gastrointestinal motor function. These outcomes demonstrate that activation of CCKA receptors by CCK-8 increases hepatic vagal afferent activity and support the view that the duodenal satiety action of CCK is mediated by the hepatic branch.

US$19.90

DOI: 10.1016/s0006-8993(97)01036-6


Other references

Aguilar, J.A.; Summerson, C., 2000: Intracardiac thrombus in antiphospholipid antibody syndrome. In this report we describe the case of a 19-year-old woman who had right-sided hemiparesis. In search of a source of embolism, we performed transthoracic echocardiography, which showed a large, complex, and irregular multilobulated left ventricle...

Zhai, H.; Nakade, K.; Mitsumoto, Y.; Fukuyama, Y., 2003: Honokiol and magnolol induce Ca2+ mobilization in rat cortical neurons and human neuroblastoma SH-SY5Y cells. We examined the intracellular Ca(2+) response in primary cultured rat cortical neurons and human neuroblastoma SH-SY5Y cells by Fluo 3 fluorescence imaging analysis. In these two kinds of neuronal cells, honokiol and magnolol increased cytoplasmic...

Komura, T.; Nagayama, H., 1983: Effect of unsaponifiable lipid components from the red alga Porphyra tenera on pancreatic carboxylesterase activity toward triacetin in vitro. Agricultural and Biological Chemistry 47: 3-7

Beckedahl Heinrich R.; Moodley Magandaran, 1997: Road induced accelerated soil erosion forms; their classification and potential significance. Supplementi di Geografia Fisica e Dinamica Quaternaria (Testo Stampato) 3, Part 1: 74

Lin, N S.; Hsu, Y H., 1998: Satellite RNA from bamboo mosaic virus as a vector for foreign gene expression in plants. Official Gazette of the United States Patent & Trademark Office Patents 1217(3): 2642, Dec 15

Jürgensen, N.; Petersen, P.E.; Ogawa, H.; Matsumoto, S., 2013: Translating science into action: periodontal health through public health approaches. Clinical and public health research data have shown that a number of individual, professional and community health measures may be valuable in preventing the major oral diseases. The fundamental gap in knowledge, however, is not confined to '...

Biurbanov, I., 1965: Method Of Threshold Cephalography. Gigiena i Sanitariia 30: 89-91

Drexler, S.K.; Kong, P.L.; Wales, J.; Foxwell, B.M., 2008: Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis. Rheumatoid arthritis is a multisystemic auto-inflammatory disease affecting up to 1% of the population and leading to the destruction of the joints. Evidence exists for the involvement of the innate as well as the adaptive immune systems in the pa...

Kaisin Felix Jr., 1956: Le role de la substitution dans lalteration meteorique des roches sedimentaires, specialement des calcaires. Discusses the role of substitution in surface weathering of sedimentary rocks, with special reference to the alteration of limestones and dolomites of Belgium and the Belgian Congo as examples of alteration under temperate and tropical climatic co...

Hall, A.V.; Hall, E.V.; Perry, J.L., 2016: Black and blue: Exploring racial bias and law enforcement in the killings of unarmed black male civilians. In late 2014, a series of highly publicized police killings of unarmed Black male civilians in the United States prompted large-scale social turmoil. In the current review, we dissect the psychological antecedents of these killings and explain how...