geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

CNTF exerts opposite effects on in vitro development of rat and chick photoreceptors


, : CNTF exerts opposite effects on in vitro development of rat and chick photoreceptors. Neuroreport 7(3): 697-700

Effects of ciliary neurotrophic factor (CNTF) on photoreceptor development in dissociated cultures of embryonic chick and newborn rat retina were studied using opsin immunoreactivity to characterize photoreceptor differentiation. In the presence of CNTF, the number of photoreceptors was increased by up to 200% in chick cultures, but was reduced by 82-99% in rat cultures. The EC50 determined for CNTF effects in chick and rat cultures were 0.06 ng ml-1 and 0.02 ng ml-1, respectively. By studying the time course of in vitro development we showed that CNTF transiently stimulated the generation of photoreceptors from opsinnegative precursor cells of chick retina, but completely prevented the same process in rat cultures. These results suggest that CNTF is involved in the regulation of photoreceptor development, but that it can have different actions in the two species, at least in vitro.

US$19.90

PMID: 8733724

DOI: 10.1097/00001756-199602290-00004


Other references

Artsybashev, E.S.; Lorberbaum, V.G.; Smirnova, K.V.; Akakiev, F.I.; Vasil' ev, O.A., 1979: Using bischofite solutions to fight forest fires. Trials in the USSR are described on the use of solutions of bischofite [hydrated magnesium chloride] as a fire retardant. The optimum concn. is 5-7%; details are given of the preparation of the solution and its application. The optimum dosage depe...

Biggs, W.F., 1996: Placement of a custom implant provisional restoration at the second-stage surgery for improved gingival management: a clinical report. Journal of Prosthetic Dentistry 75(3): 231-233

Marker, D.R.; LaPorte, D.M.; Seyler, T.M.; Ulrich, S.D.; McGrath, M.S.; Frassica, F.J.; Mont, M.A., 2009: Orthopaedic journal publications and their role in the preparation for the orthopaedic in-training examination. Journal of Bone and Joint Surgery. American Volume 91 Suppl 6: 59-66

Shidomoto Y.; Uemura Y., 1983: Development of water resources in Libya. Nippon Chikasui Gakai Kaishi = Journal of Japanese Association of Groundwater Hydrology 25(4): 193-200

Chen, C-Yen.; Fujimiya, M.; Laviano, A.; Chang, F-Young.; Lin, H-Chieh.; Lee, S-Dong., 2010: Modulation of ingestive behavior and gastrointestinal motility by ghrelin in diabetic animals and humans. Acyl ghrelin, a 28-amino acid peptide hormone, is the endogenous cognate ligand for the growth hormone secretagogue receptor. Ghrelin is involved in stimulating growth hormone release, eliciting feeding behavior, inducing adiposity and stimulating...

Olson H.C., 1986: Paleoenvironment and depositional environment of Miocene Olcese Sand, Bakersfield, California. AAPG Bulletin 70(4): 475

Kraenz, S.; Fricke, L.; Wiater, A.; Mitschke, A.; Breuer, U.; Lehmkuhl, G., 2004: Prevalence and stress factors of sleep disorders in children starting school. Epidemiological studies of sleep disturbances in preschool and school-aged children are under-represented in international clinical research. Based on this fact we investigated the prevalence of insomnia and parasomnia in a representative sample o...

Lukat, K.; Rivas, P.; Roger, A.; Kowalski, M.; Botzen, U.; Wessel, F.; Sanquer, F.; Agache, I.; Izquierdo, I., 2013: A direct comparison of efficacy between desloratadine and rupatadine in seasonal allergic rhinoconjunctivitis: a randomized, double-blind, placebo-controlled study. H1-antihistamines are recommended as the first-line symptomatic treatment of allergic rhinitis. The objective of this study was to evaluate the effects of rupatadine (RUP) versus desloratadine (DES) in subjects with seasonal allergic rhinitis (SAR...

Liao Zewen; Geng Ansong, 2002: Characterization of nC (sub 7) -soluble fractions of the products from mild oxidation of asphaltenes. A significant quantity of hydrocarbons (including alkanes) is occluded in the skeleton of the asphaltene molecule. The hydrocarbons are probably remnants of the "original oil" which had been retained within the asphaltene matrix and prot...

Seo, J.Hee.; Mittal, R., 2011: A Sharp-Interface Immersed Boundary Method with Improved Mass Conservation and Reduced Spurious Pressure Oscillations. A method for reducing the spurious pressure oscillations observed when simulating moving boundary flow problems with sharp-interface immersed boundary methods (IBMs) is proposed. By first identifying the primary cause of these oscillations to be t...