geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Catecholamine-induced cardiac hypertrophy: Significance of proto-oncogene expression


, : Catecholamine-induced cardiac hypertrophy: Significance of proto-oncogene expression. Journal of Molecular Medicine (Berlin) 75(11-12): 849-859

The effect of P- and o-adrenergic stimulation on cardiovascular function and development of cardiac hypertrophy was studied in rats by measuring the heart weight/body weight and cardiac RNA/DNA ratios. P-Receptor stimulation with isoproterenol over 3 days induced an increase in the biosynthesis of cardiac adenine nucleotides, myocardial protein synthesis, and the heart weight/body weight ratio. The isoproterenol-induced metabolic effects were prevented by simultaneous P-adrenergic blockade with propranolol. alpha-Adrenergic stimulation with norenephrine for 3 days induced an increase in heart rate, total peripheral resistance, the myocardial RNA/DNA, and left ventricular weight/body weight ratio. The calcium antagonist verapamil prevented the hemodynamic changes but did not influence the development of cardiac hypertrophy. The alpha-adrenergic blocker prazosin reversed the norfenephrine-induced functional changes and prevented cardiac hypertrophy. Norepinephrine was infused into isolated perfused working rat hearts to elucidate some molecular biological changes that precede the development of cardiac hypertrophy. It increased transiently and sequentially the mRNA of c-fos and c-myc. This enhancement occurred at about the same time as that induced by elevation of pre- and afterload but was more pronounced. These findings were compared with those obtained in other studies assessing the effects of catecholamines on proto-oncogene expression. Combination of norepinephrine with pre- and afterload elevation induced the c-fos mRNA signal to appear earlier, to be more pronounced, and to persist for a longer period of time. Similar results were obtained in regard to the c-myc mRNA. These findings indicate that the combination of two hypertrophy-inducing stimuli which may cause a higher degree of cardiac hypertrophy in vivo induce an earlier, more pronounced, and longer lasting expression of the proto-oncogenes c-fos and c-myc.

US$19.90

DOI: 10.1007/s001090050176


Other references

Hoier, B.; Passos, M.; Bangsbo, J.; Hellsten, Y., 2013: Intense intermittent exercise provides weak stimulus for vascular endothelial growth factor secretion and capillary growth in skeletal muscle. The effect of acute intense intermittent exercise compared with moderate-intensity exercise on angiogenic factors and the effect of 4 weeks of intense intermittent training on capillary growth were examined in nine healthy young men, preconditione...

Raviola G.; Raviola E., 1967: Inst light microscopic and inst electron microscopic observations on the inner plexiform layer of the rabbit retina. American Journal of Anatomy 120(3): 403-426

Eberhart J.; Coffing S.L.; Anderson J.N.; Marcus C.; Kalogeris T.J.; Baird W.M.; Park S.S.; Gelboin H.V., 1992: The time dependent increase in the binding of benzo alpha pyrene to dna through dextro anti benzo alpha pyrene 7 8 diol 9 10 epoxide in primary rat hepatocyte cultures results from induction of cytochrome p450ia1 by benzo alpha pyrene treatment. The proportion and amount of benzo[a]pyrene (B[a]P) that binds to DNA through the carcinogenic (+)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide [(+)-anti-BPDE] increases with time to exposure to B[a]P in cell cultures derived from a number of species...

Achten G.; Ledoux M.; Wanet J.; Gourdain J.M., 1977: Dermal organized deposits in a case of systemic lupus erythematosus. Journal of Cutaneous Pathology 4(4): 217

Sun, L.; Navara, C.; Sensel, M.; Sather, H.; Uckun, F.M., 1998: Ikaros gene mutations and expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia. Blood 92(10 SUPPL 1 PART 1-2): 152A, Nov 15

Guez, D., 2013: A common pesticide decreases foraging success and survival in honey bees: questioning the ecological relevance. Frontiers in Physiology 4: 37-37

Widmer, C.G.; Lund, J.P.; Feine, J.S., 1990: Evaluation of diagnostic tests for TMD. Journal of the California Dental Association 18(3): 53-60

Nelson, D., 2007: Prevention and treatment of sleep deprivation among emergency physicians. Emergency physicians commonly experience sleep deprivation because of the need to work shifts during evening and late night hours. The negative effects of this problem are compounded by job stress and traditional methods of scheduling work shifts....

Strache, R-R.; Madas, K., 1988: Nebelkrahen (Corvus corone cornix) suchen Fruchtstande von Sonnenblumen (Helianthus annuus) zur Nahrungssuche auf. Beitraege zur Vogelkunde, 342-3: 201-202

Stefanis, E. de; Galterio, G.; Manamana, P.N. (Novaro Manmanana, P); Sgrulletta, D.; Stefanini, R., 1978: Phosphoenolpyruvate, ribulose 1,5-diphosphate carboxylase and glutamate dehydrogenase activities in seedlings of maize inbreds and their hybrids. Combining ability and heterosis for enzyme activity was assessed in a diallel cross of five inbreds. Overall, general combining ability (GCA) effects were greater than specific combining ability (SCA) effects. B14A had the highest GCA for both car...