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Cerebrospinal fluid monoamine metabolites in childhood-onset schizophrenia

, : Cerebrospinal fluid monoamine metabolites in childhood-onset schizophrenia. American Journal of Psychiatry 154(1): 69-74

Objective: Pediatric studies of cerebrospinal fluid (CSF) monoamine metabolites in childhood-onset schizophrenia may help to elucidate both pathophysiology and treatment response in early-onset psychosis. Method: CSF homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) and serum prolactin were measured during drug-free and antipsychotic medication conditions in 18 patients (mean age=14.2 years, SD=1.7) who had onset of schizophrenia by age 32 (mean age at onset=9.9 years, SD= 1.8). Relationships between changes in CSF monoamines and serum prolactin and clinical outcome were examined, and the degree of change in CSF monoamines in response to clozapine treatment was compared with that for 16 patients with later-onset schizophrenia. Results: Despite patients' significant clinical improvement with treatment, CSF monoamine concentrations and ratios of HVA/5-HIAA and HVA/MHPG did not significantly change with 6 weeks of either haloperidol or clozapine treatment. Serum prolactin levels increased during haloperidol treatment. Clozapine had similar effects on CSF monoamines in patients with childhood- and later-onset schizophrenia. Conclusions: While these data are compatible with continuity between childhood- and later-onset schizophrenia, they also highlight the complexity of the biochemical events mediating clinical changes in schizophrenia.


PMID: 8988961

DOI: 10.1176/ajp.154.1.69

Other references

Davis, W.L.; Matthews, J.L.; Shibata, K.; Kipnis, M.; Farmer, G.R.; Cortinas, E.; Meiyr, J.C.; Goodman, D.B., 1989: The immunocytochemical localization of superoxide dismutase in the enterocytes of the avian intestine: the effect of vitamin D3. Both light microscopical and electron microscopical immunocytochemical techniques were utilized to localize CuZn-superoxide dismutase (SOD) in the duodenum of normal, rachitic and vitamin-D3-replete chicks. This enzyme catalyses the dismutation of...

Popova Ralcheva S., 1987: A study on correlation between behavior of laying hens and some parameters of reproductivity. A two-stage experiment was conducted on the behaviour of 160 laying hens of the Warren hybrid, divided in groups of 20 hens with two cocks in each group. In the first (preliminary) stage were observed the behavioural parameters as number of bill s...

Jiang, Y.; Nishikawa, R.M.; Schmidt, R.A.; Metz, C.E., 2006: Comparison of independent double readings and computer-aided diagnosis (CAD) for the diagnosis of breast calcifications. The aim of the study is to compare independent double readings by radiologists and computer-aided diagnosis (CAD) in diagnostic interpretation of mammographic calcifications. Ten radiologists independently interpreted 104 mammograms containing clu...

Greenwood J.G.; Fielder D.R., 1988: Larval development of three species of sesarma crustacea brachyura grapsidae from eastern australia. All zoeal stages and the megalopa of Sesarma (P.) erythrodactyla Hess, and the first zoeal stages of Sesarma (B.) smithii H. Milne-Edwards and Sesarma (P.) messa Campbell, are described and figured from eastern Australian specimens. Larvae of 16 S...

Smirnoff, W.A., 1971: Effect of chitinase on the action of Bacillus thuringiensts. Bacillus thuringiensis is lethal to Choristoneura fumiferana (Clem.), but its action is slow, and preliminary tests of the value of including chitinase in preparations of this bacterium applied against the larvae to break down the gut chitin and f...

Back, T.G.; Janzen, L.; Nakajima, S.K.; Pharis, R.P., 2001: Synthesis and Biological Activity of 25-Methoxy-, 25-Fluoro-, and 25-Azabrassinolide and 25-Fluorocastasterone: Surprising Effects of Heteroatom Substituents at C-25. The CuCN-catalyzed addition of 2-propenylmagnesium bromide to (threo-2R,3S,5alpha,22R,23R,24S)-23,24-epoxy-6,6-(ethylenedioxy)-2,3-(isopropylidenedioxy)-26,27-dinorcholestan-22-ol (11a) afforded the corresponding Delta(25)-22,23-diol 12. This was...

Adrian T.E.; Bloom S.R.; Polak J.M., 1981: Regulatory peptides of the fore gut. Baron, J H And F G Moody (Ed ) Butterworths International Medical Reviews: Gastroenterology, Vol 1 Ix+324p Butterworths, Inc : Woburn, Mass , Usa; London, England Illus P67-107

McGarvey, W.C.; Singh, D.; Trevino, S.G., 1996: Partial Achilles tendon ruptures associated with fluoroquinolone antibiotics: a case report and literature review. Fluoroquinolone antibiotics (such as olprofloxacin, pefloxacin, ofloxacin, norfloxacin, temafloxacin, etc.) have recently been implicated in the etiology of Achilles tendinitis and subsequent tendon rupture. We report on a patient with bilateral p...

Le, T.P.i; Freudenthal, F.; Sievert, H.; Vaessen, P.; Grabitz, R., 2001: Transcatheter occlusion of subaortic ventricular septal defect using a Nitinol coil Initial clinical results. Circulation 104(17 Supplement): II 593, October 23

Hunt J.W., 1989: Ash content and composition of the Permian coals. Bulletin Australia, Bureau of Mineral Resources, Geology and Geophysics: 277-296. 1989.