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Chromosomal localization and genomic cloning of the mouse alpha-tropomyosin gene Tpm-1

, : Chromosomal localization and genomic cloning of the mouse alpha-tropomyosin gene Tpm-1. Genomics 17(2): 519-521

In vertebrates, the alpha-tropomyosin gene, Tpm-1, codes for at least 9 tropomyosin isoforms that are expressed by tissue-specific alternative splicing. Using interspecies backcrosses, we have localized Tpm-1 on mouse chromosome 9, cen-Cyp1a2-Tpm-1-Mod-1-Mylc-Scn5a, near the d-se region. The restriction fragment length variant used for chromosomal assignment, as well as other restriction fragments hybridizing to a 3'-specific alpha-tropomyosin cDNA probe in genomic Southern blots, was investigated by cloning 17.5-kb of Tpm-1. The same restriction patterns were observed, proving the identity of the mapped and the cloned gene. The identity was supported by sequencing the 3' end of the gene.


PMID: 8406508

DOI: 10.1006/geno.1993.1361

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