+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Chromosome rearrangements at telomeric level in hematologic disorders

, : Chromosome rearrangements at telomeric level in hematologic disorders. Cancer Genetics & Cytogenetics. 83(2): 121-126

Following retrospective screening of our karyotype data from 414 consecutive non-childhood, neoplastic, and preneoplastic hematologic diseases, we have isolated 11 cases with alterations involving one or two chromosome termini, including: a) nonclonal telomeric associations (tas), b) subclonal terminal rearrangements consisting of additional (add) material of unknown origin fused at the end of the chromosome, c) clonal telomere-centromere fusion (t telcen) with pseudodicentric structure. Most of these abnormalities were present in karyotypes with multiple alterations and associated to an evolutive stage of the disease (9 of 94 cases studied in progression, including three of 22 CML studied in blast crisis). The immunophenotype of the cell populations was lymphoid in eight cases, six of which were NHL, and myeloid, erythroid, and undifferentiated in the other three. More data on telomeric abnormalities may clarify whether there is ubiquitous genomic instability of neoplastic cells or an inborn cell lineage predisposition favoring rearrangements involving telomeres.


PMID: 7553581

DOI: 10.1016/0165-4608(94)00222-w

Other references

Markus, M.B.; Lugt, J.J. van der; Dubey, J.P., 2004: Sarcocystosis. The life cycle of Sarcocystis, and the epidemiology, pathogenesis clinical signs, pathology, diagnosis, differential diagnosis and control of sarcocystosis (treatment with halofuginone) in domestic animals are described. The Sarcocystis species wi...

Kettlewell, M.; Nowers, A.; White, R., 1972: Effect of digoxin on human red blood cell electrolytes. Red blood cell electrolytes were measured during 48 h after administration of digoxin to twelve patients. The concentrations of some red cell electrolytes changed: sodium increased while potassium decreased significantly. These findings agree with...

Maatouk, F.; Ben Hamda, K.; Mejdoub, M.A.; Betbout, F.; Piéchaud, J.F.; Mootamri, F.; Jomma, W.; Thaouaba, H.; Hassine, M., 2009: Closure of ventricular septal defects in an infant. La Tunisie Medicale 86(12): 1103-1105

Adams, J.B.; Romdalvik, J.; Ramanujam, V.M.Sadagopa.; Legator, M.S., 2007: Mercury, lead, and zinc in baby teeth of children with autism versus controls. This study determined the level of mercury, lead, and zinc in baby teeth of children with autism spectrum disorder (n = 15, age 6.1 +/- 2.2 yr) and typically developing children (n = 11, age = 7 +/- 1.7 yr). Children with autism had significantly...

Lecomte Paul; Hau Jean Michel; Maton Daniel, 1996: Heavy metal stability in soils of industrial waste regions. Reunion Annuelle des Sciences de la Terre 16: 171

Scheres, Geer., 1994: First reintroduction of an endangered cracid. WPA News. February; 43: 26-29

Holmberg, M.; Sahana, G.; Andersson-Eklund, L., 2007: Mapping of quantitative trait loci affecting fertility traits in Finnish Ayrshire. We previously mapped a quantitative trait locus (QTL) affecting the trait non-return rate at 56 days in heifers to bovine chromosome 9. The purpose of this study was to confirm and refine the position of the QTL by using a denser marker map and fi...

Meredith, H.R.; Lopatkin, A.J.; Anderson, D.J.; You, L., 2016: Bacterial temporal dynamics enable optimal design of antibiotic treatment. There is a critical need to better use existing antibiotics due to the urgent threat of antibiotic resistant bacteria coupled with the reduced effort in developing new antibiotics. β-lactam antibiotics represent one of the most commonly used clas...

Park NamGeon; O.W.onYong; K.S.oBong; Yang ChangBum; Lee WangShik; Kang SuWon, 1998: Growth performance and haematological values during the grazing period in Korean native cattle introduced to Cheju Island. To investigate adaptability to Theileria sergenti infection and bracken poisoning during the grazing period, changes in liveweight gain and haematological values of Korean native cattle introduced to Cheju Island were compared with those of cattle...

Stejskal, D.; Pastorková, R.; Franková, M.; Bartek, J.; Horalík, D., 1999: Benefit of direct determination of LDL-cholesterol (comparison with LDL measurement using calculated estimates. Treatment of dyslipidemia and its frequently associated complications (manifest atherosclerosis) is very pretentious from the economic aspect. Diagnostic and therapeutic criteria are based mainly on biochemical analyses. Although demands on labora...