+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus

, : Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus. Biochemical & Biophysical Research Communications. 231(2): 481-487

We identified a novel gene, kf-1, highly expressed in the normal cerebellum but not in the cerebral cortex, the expression of which could have been augmented in the cerebral cortex of a sporadic Alzheimer's disease patient. We cloned human and mouse entire kf-1 cDNAs encoding conserved 79 kDa proteins containing a zinc-binding RING-H2 finger motif at the carboxy-terminus as found in acetylcholine receptor-associated protein (RAPsyn). The 3'-untranslated regions are highly conserved between human and mouse as to constitute a common mRNA secondary structure. In situ hybridization analysis of mouse brain sections revealed strong kf-1 expression in the cerebellum and hippocampus. We propose that KF-1 is involved in membranous protein-sorting apparatus similarly to RAPsyn. We mapped the human kf-1 gene to 2p11.2.


PMID: 9070305

DOI: 10.1006/bbrc.1996.6033

Other references

Quillian, M.R., 1967: Word concepts: a theory and simulation of some basic semantic capabilities. Behavioral Science 12(5): 410-430

Margeat, H., 1989: Therapeutic risk in surgery. Chirurgie; Memoires de L'academie de Chirurgie 115(9): 615-8; Discussion 619

Gauthier, M.; Boily, C.; Duval, L., 2001: Young people's life styles and cultural behaviour: the homogenization of culture and the personalization of practices?. Changes in lifestyles have coincided with an increase in the amount of time that young people devote to cultural practices. Does an increase in the number of years of schooling have something to do with the interest shown by young adults for readi...

MacDougall, L.; Fyfe, M.; McIntyre, L.; Paccagnella, A.; Cordner, K.; Kerr, A.; Aramini, J., 2004: Frozen chicken nuggets and strips--a newly identified risk factor for Salmonella Heidelberg infection in British Columbia, Canada. Salmonella enterica var. Heidelberg was isolated from an unusual food source during routine case follow-up, prompting a case control investigation of frozen chicken nuggets and strips. Most frozen nuggets and strips are raw; however, par-frying le...

Depping, R.; Hägele, S.; Wagner, K.F.; Wiesner, R.J.; Camenisch, G.; Wenger, R.H.; Katschinski, Dörthe.M., 2004: A dominant-negative isoform of hypoxia-inducible factor-1 alpha specifically expressed in human testis. Spermatogenesis in the seminiferous tubuli of the testis occurs under a high proliferation rate, suggesting considerable oxygen consumption. Because of the lack of blood vessels, the oxygen partial pressure in the lumen of these tubuli is very low...

Pineda Ofreneo, R., 1985: Women of the soil: an alternative Philippine report on rural women. Based on information gathered by the Philippine Women's Research Collective the study seeks to define the term 'rural women' who numbered 14.8 million in 1980, 62% of the total female population. The study finds that rural women com...

Greenberg, P.A.; Hortobagyi, G.N.; Smith, T.L.; Ziegler, L.D.; Frye, D.K.; Buzdar, A.U., 1996: Long-term follow-up of patients with complete remission following combination chemotherapy for metastatic breast cancer. Purpose: To determine the long-term clinical course of patients with metastatic breast cancer (MBC) who achieved a complete remission with doxorubicin-alkylating agent-containing combination chemotherapy programs. Patients and Methods: To assess t...

Eybert, M.C.; Constant, P., 1992: Validity of fecal sac analysis in the study of the diet of nestlings of the European linnet (Carduelis cannabina). Diet was studied in nestlings of the European Linnet (Carduelis cannabina L.) by analyzing fecal sacs, the only method that allows continuous sampling of the diet to the end of the nesting period. The validity of the method was tested by comparing...

Georges, A.; Page, J.; Duvernay, G., 1962: Pharmacology of AC 3810 (original derivative of 2-benzylimidazo-4,5-d-pyrimidine). Therapie 17: 211-225

Martin, Rn, 1991: Animal health post-1992. Proceedings of a meeting Society for Veterinary Epidemiology and Preventive Medicine: -6