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Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons


, : Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons. Neuroscience Letters. 231(1): 33-36

Noxious heat is able to activate heat-sensitive nociceptors in the skin very rapidly, but little is known about the mechanisms by which heat is transduced. We used the whole-cell patch-clamp technique to study the effects of noxious heat and capsaicin on freshly dissociated rat dorsal root ganglion neurons in vitro. Using temperatures between 41 degree C and 53 degree C, 8 of 19 small neurons (vphi ltoreq 30 mu-m) exhibited a heat-evoked inward current. All heat-sensitive neurons tested were also capsaicin-sensitive. Moreover, the heat response tended to be enhanced after capsaicin (360 +- 150 pA versus 125 +- 45 pA, P lt 0.1, n = 7). Two of five heat-insensitive neurons were excited by capsaicin; both neurons developed a heat response after capsaicin. Large neurons (vphi gt 30 mu-m) did not respond to heat (on), and were not sensitive to capsaicin either. These findings indicate that heat stimuli may directly activate capsaicin-sensitive primary nociceptive afferents.

US$19.90

PMID: 9280161

DOI: 10.1016/s0304-3940(97)00533-8


Other references

Hofmeier, G.; Vecsei, P.; Wolff, H.P., 1970: The effect of the surgical intervention on the desoxycorticosterone secretion rate (DOC-SR). Der Anaesthesist 19(2): 79-82

Takac, I.; Gorisek, B., 2006: Serum CA 125 levels and lymph node metastasis in patients with endometrial cancer. The aim of this study was to evaluate the correlation of preoperative serum CA 125 levels and lymph node metastasis in patients with endometrial cancer.Preoperative levels of serum CA 125 were determined in 64 patients with endometrial cancer trea...

Dafert, O.; Kwizda, R., 1926: Preliminary report of method for determining small amounts of volatile oils in drugs by means of hemolysis. A method is described for determining the hemolytic value of the extract of drug and its value as a measure of the amount of oil.

Roberts, S.M.; Peskoe, L.Y.; Fader, D.E., 1952: Adenoma of the jejunum; a case report. Radiology 59(3): 409-414

Zheng, Z.; Hungund, B.L., 1998: Effects of acute and chronic ethanol exposure on fatty acid ethyl ester synthases in mouse cerebellar membranes. Fatty acid ethyl esters (FAEE), the products of esterification of fatty acids with ethanol (EtOH), are shown to cause organ injury in chronic alcohol abusers. Their formation is catalysed by the enzyme FAEE synthase which is present in both animal...

Cattell, R.B., 1950: Causes of unsatisfactory results after operation on the gallbladder and bile ducts. Postgraduate Medicine 7(5): 351-356

Anonymous, 1986: 1986 guide to biotechnology products and instruments. Guide to scientific instruments. Science 232 Pt 2: G1-224

Sartawi I.A.; A.B.hrani I.R.; A.N.aman Y.D., 1972: Myo cardial re vascularization by the acupuncture technique a preliminary report. Journal of the Faculty of Medicine Baghdad 14(3): 87-94

Yonemoto, R.E., 1988: CA 125 assay--should it be used with other tests?. Oncology 2(12): 12-12

Anaissie, E.; Fainstein, V.; Samo, T.; Bodey, G.P.; Sarosi, G.A., 1988: Central nervous system histoplasmosis. An unappreciated complication of the acquired immunodeficiency syndrome. Involvement of the central nervous system (CNS) by Histoplasma capsulatum is a rare event. It is usually not included in the differential diagnosis of CNS lesions in patients with acquired immunodeficiency syndrome (AIDS). Herein are described fou...