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Comparative outcome of heart-lung and lung transplantation for pulmonary hypertension

, : Comparative outcome of heart-lung and lung transplantation for pulmonary hypertension. Journal of Thoracic and Cardiovascular Surgery 106(2): 299-307

Despite the development of several lung transplantation procedures, the most advantageous for pulmonary hypertension remains controversial. Between 1986 and February 1992, 30 patients with end-stage primary pulmonary hypertension (n = 24), chronic pulmonary embolism (n = 4), and hystiocytosis X (n = 2) underwent heart-lung (n = 21), double lung (n = 8), or single lung (n = 1) transplantation. Indications for double lung transplantation were similar to those for heart-lung transplantation, and the preoperative clinical and hemodynamic parameters were not significantly different between the two groups. There were no intraoperative deaths, but two reoperations were needed for pleural hematoma. Five early deaths were related to graft failure (two heart-lung transplantations), mediastinitis (one heart-lung transplantation), multiorgan failure (one double lung transplantation), and aspergillosis (one double lung transplantation). There was a similar improvement in early (days 0 and 2) and late (6 months postoperatively) right-sided hemodynamic function in patients undergoing heart-lung and double lung transplantation. Three double lung transplant recipients had early and reversible left ventricular failure. The early postoperative course of the one patient who had single lung transplantation was characterized by severe pulmonary edema, left ventricular failure, and persistent desaturation and later on by moderate pulmonary hypertension and an important ventilation/perfusion mismatch. The pulmonary function results were also similar in the heart-lung and double lung transplantation groups. The overall projected 2- and 4-year survivals were 49% and 41%, respectively, and were not significantly different between the heart-lung and double lung recipients. Results demonstrate that heart-lung and double lung transplantation are equally effective in obtaining early and durable right-sided hemodynamic and respiratory improvement and similar respiratory function. In patients with pulmonary hypertension, double lung transplantation should be preferred to single lung transplantation because of the critical postoperative course and the uncertain long-term results of single lung transplantation.


PMID: 8341071

Other references

Ozieblo, L.; Paszko, Z., 1964: Activity Of Beta-Glucuronidase Of The Blood Serum In Menstruating, Pregnant And Puerperal Women. Ginekologia Polska 35: 361-365

Haustein, U.F., 1991: Pyrethrin and pyrethroid (permethrin) in the treatment of scabies and pediculosis. The history and development of pyrethrum, the natural pyrethrins and synthetic pyrethroids and their insecticidal properties, chemical structure and toxic and allergic side-effects are reported. Permethrin is stressed as a photostable insecticide...

Drozdowski, S., 1963: Experimental Study On Deep Hypothermia. Polski Przeglad Chirurgiczny 35: 225-232

Hurst Richard W., 1986: Chemical and Sr isotopic variations during diagenesis of Miocene siliceous sediments of the Monterey Formation, California; discussion of the Sr isotopic data and its relevance to the timing of Monterey Formation fracturing. Journal of Sedimentary Petrology 56(4): 569-573

Pekarek Alfred H., 2004: Tectonic implications of Tertiary paleo-stream channel deposits and erosion surfaces in the Rattlesnake Hills, Natrona County, Wyoming. Wyoming Geo-Notes 79: 31-35

Yamaguchi, H., 2000: Immunoserodiagnosis of histoplasmosis. Nihon Rinsho. Japanese Journal of Clinical Medicine 57 Suppl: 227-230

Yoshimura, K.; Olino, K.; Edil, B.H.; Schulick, R.D.; Oka, M., 2010: Immuno- and gene-therapeutic strategies targeted against cancer (mainly focusing on pancreatic cancer). Current treatment modalities of surgical resection and chemotherapy against cancers have improved survival. However, mortality from tumor recurrence remains high. Immunotherapy and gene therapy are potential additions to the treatment arsenal in t...

Firme, W.A.; Carvalho, G.L.; Lima, D.L.; Lopes,; Montandon, I.D.; Santos Filho, F.; Shadduck, P.P., 2016: Low-Friction Minilaparoscopy Outperforms Regular 5-mm and 3-mm Instruments for Precise Tasks. Therapeutic laparoscopy was incorporated into surgical practice more than 25 y ago. Several modifications have since been developed to further minimize surgical trauma and improve results. Minilaparoscopy, performed with 2- to 3-mm instruments was...

Heilman, R.S., 1994: Patient confidentiality: radiologists can do better. Radiographics 14(2): 254-254

Tang, X.; Di, X.; Zhong, Z.; Xie, Q.; Chen, Y.; Wang, F.; Ling, Z.; Xu, P.; Zhao, K.; Wang, Z.; Liu, L.; Liu, X., 2016: In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes. l-Corydalmine (l-CDL) was under development as an oral analgesic agent, exhibiting potent analgesic activity in preclinical models. The objective of this study was to compare metabolic profiles of l-CDL in liver microsomes from mouse, rat, monkey,...