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Comparative study for the differentiation of allergic and irritant contact dermatitis in mice

, : Comparative study for the differentiation of allergic and irritant contact dermatitis in mice. Seoul Journal of Medicine 34(1): 49-54

Our study was performed to compare the differences between allergic and irritant contact dermatitis in BALB/c mice. Allergic reaction was induced by a sensitizing regimen of 2,4-dinitro-1-fluorobenzene (DNFB) and irritant reaction by 10% sodium lauryl sulfate (SLS). The following differences were noted: 1) the mice with irritant reaction showed an earlier peak of-ear swelling, 2) increasing number of Langerhans cells (LCs) in allergic reaction but decreasing number of LCs in irritant reaction was observed at 48 hr after challenge of DNFB or SLS, and 3) induction of la (+) keratinocytes was found only in allergic reaction. lt was suggested that la (+) keratinocytes play an active role in the mechanism of allergic contact dermatitis.


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