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Correlation between myocardial contractile force and cytosolic inorganic phosphate during early ischemia


, : Correlation between myocardial contractile force and cytosolic inorganic phosphate during early ischemia. American Journal of Physiology 272(3 Pt 2): H1333-H1341

To test the role of inorganic phosphate (P-i) in downregulation of myocardial contractile force at the onset of ischemia, P-i of rat hearts was determined with 31P nuclear magnetic resonance spectroscopy. Forty cycles of brief hypoperfusion (30% of baseline flow for 33 s) were used to achieve a time resolution of 0.512 s for comparing dynamic changes in P-i and contractile force. Initial control values of left ventricular developed pressure (LVP), heart rate, and oxygen consumption were 136 +- 11 mmHg, 236 +- 4 beats/min, and 95 +- 3 mu-l O-2 cntdot min-1 cntdot g-1; these values were unchanged at the end of the experiment. During the first 10 s of hypoperfusion, P-i increased at a rate (percentage of the total observed change) faster than the decrease in LVP; P-i and LVP then changed at the same rate during the remainder of the hypoperfusion. ADP did not change in advance of LVP. Intracellular pH did not change. The results indicate that P-i plays an important role in initiating the downregulation of myocardial contractile force at the onset of ischemia. Perfusion pressure also declined faster than LVP at the onset of ischemia, indicating potential importance of vascular collapse in contractile downregulation during early ischemia.

US$29.90

PMID: 9087609


Other references

Yamada, K.; Scalea, J., 2012: Thymic transplantation in pig-to-nonhuman primates for the induction of tolerance across xenogeneic barriers. With the advent of knockout pigs for α1,3-galactosyltransferease (GalT-KO, which lack a cell-surface antigen to which humans have preformed antibodies), investigators have extended the survival of life-supporting xenorenal grafts. However, despit...

Mercer, C.F.; Wigley, P.J., 1987: A microsporidian pathogen of the poroporo stem borer, Sceliodes cordalis Dbld Lepidoptera Pyralidae 1 Description and identification. A microsporidian pathogen of the poroporo stem borer, Sceliodes cordalis , is described in terms of its developmental cycle, morphology, and host specificity. The characteristics of the pathogen, a Nosema species, were indistinguishable from 11 ot...

Nichols-Casebolt, A.; Macrina, F.L., 2015: Current Perspectives Regarding Institutional Conflict of Interest : Commentary on "Institutional Conflicts of Interest in Academic Research". Science and Engineering Ethics: -

Cottu, Y., 2003: Weed control plan. A tool for protection of the environment. A weed control plan constitutes a type of audit permitting readjustment of practices, areas treated and the actual needs, with respect for the environment and public safety. Weed control in green spaces is discussed, with notes on chemical, manual...

Vierling, E.; Key, J.L., 1985: Ribulose 1,5-Bisphosphate Carboxylase Synthesis during Heat Shock. Ribulose 1,5-bisphosphate carboxylase (RuBPCase) was chosen as a model protein to study how heat shock (HS) affects both chloroplast protein synthesis and the nuclear-chloroplast interaction in production of chloroplast proteins. Experiments were...

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Kernbach, K., 1962: Schwarmer mit kurzem Russel (Lep. Sphingidae). Deutsche Entomologische Zeitschrift (NS): 9: 297-303

Ladd, R.L.; Goldstine, M.T.; Burns, O.R., 1950: A study in transplanted rat and spontaneous dog tumors of growth accelerating and inhibiting factors from duojejunal tissue of hogs, sheep, and dogs. Preliminary expts. in which tumor bearing animals were treated with crude extracts prepd. from duojejunal tissue, yielded some evidence that such extracts would modify the growth rate of the Jensen sarcoma in rats and spontaneous tumors in dogs. D...

Sidhu, M.S.; Helen, B.K.; Athwal, R.S., 1992: Fingerprinting human chromosomes by polymerase chain reaction-mediated DNA amplification. We describe here a method for DNA fingerprinting of human chromosomes of Alu-polymerase chain reaction (PCR) amplification of DNA from monochromosomal hybrids, following digestion with restriction endonucleoases. DNA digestion with restriction enz...

Luthra, M.G.; Au, K.S.; Hanahan, D.J., 1977: Purification of an activator of human erythrocyte membrane calcium plus magnesium atpase. An activator of human erythrocyte membrane (Ca2+ + Mg2+)ATPase was isolated in highly purified form from membrane free hemolysate through a combination of carboxymethyl Sephadex chromatography and preparative polyacrylamide gel electrophoresis. Th...