+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cupric and ferric ions inactivate HIV

, : Cupric and ferric ions inactivate HIV. Aids Research and Human Retroviruses 12(4): 333-337

Human immunodeficiency virus (HIV-1) was inactivated by either cupric or ferric ions when the virus was free in solution and also 3 hr after cell infection. Fifty percent inactivation of cell-free HIV was achieved with Cu(II) at a concentration between 0.16 and 1.6 mM, or by 1.8 to 18 mM Fe(III). Thus, the dose to inactivate 50% of infectious HIV (D-50) by Cu(II) or Fe(III) is higher than that reported for glutaraldehyde (0.1 mM); between the D-50 reported for sodium hypochlorite (1.3 mM) and sodium hydroxide (11.5 mM), and significantly lower than that required for HIV inactivation by ethanol (360 mM). Treatment of infected cells for 30 min at 20 degree C with 6 mM Cu(II) or Fe(III) completely inhibited the formation of syncytia and the synthesis of virus-specific p24 antigen in HIV-infected cells, while still preserving cell viability. The virucidal properties of cupric and ferric ions could be exploited for the development of novel virucidal formulations efficient against HIV.


PMID: 8906994

DOI: 10.1089/aid.1996.12.333

Other references

Yasuda F.; Nishikawa H.; Ujihashi M.; Watanabe S., 1969: Studies on life history of dipylidium caninum part 2 the ecology of the mature proglottids and the diagnostic cellophane tape method applied its biological character. Bulletin of the Nippon Veterinary & Zootechnical College (18): 122-131

Hodgkinson, S., 1995: GFP in Dictyostelium. Trends in Genetics 11(8): 327-328

Bruce, P., 1981: Hong Kong health service: all for 50p a day. Health and Social Service Journal 91(4763): 1112-1113

Laurencin, C., T.; Attawia, M., A.; Elgendy, H., E.; Herbert, K., M., 1996: Tissue engineered bone-regeneration using degradable polymers: The formation of mineralized matrices. In the development of 3-dimensional cell-polymer matrices for tissue engineering, the ability of osteoblast cells to maintain their phenotypic properties and form a mineralized matrix while seeded on the polymer surface is very important. Osteobla...

Anonymous, 1917: Boy Scouts battle Moths. In Ohio, the State has for the first time called upon the Boy Scout organization for help in the control of the tussock moth; in a two weeks' campaign in the town of Canton, 3, 000, 000 eggs were collected. It is suggested that this precedent...

Olson, S.H.; Zauber, A.G.; Tang, J.; Harlap, S., 1998: Relation of time since last birth and parity to survival of young women with breast cancer. We investigated whether survival was related to recent childbirth or parity in a cohort of 540 women diagnosed with breast cancer before the age of 45 years who were followed for up to 14 years. Women who had given birth within 2 years before thei...

Pilgaard, L.; Lund, P.; Duroux, M.; Lockstone, H.; Taylor, J.; Emmersen, J.; Fink, T.; Ragoussis, J.; Zachar, V., 2009: Transcriptional signature of human adipose tissue-derived stem cells (hASCs) preconditioned for chondrogenesis in hypoxic conditions. Hypoxia is an important factor involved in the control of stem cells. To obtain a better insight into the phenotypical changes brought about by hypoxic preconditioning prior to chondrogenic differentiation; we have investigated growth, colony-form...

Stice, E., 2002: Risk and maintenance factors for eating pathology: a meta-analytic review. This meta-analytic review of prospective and experimental studies reveals that several accepted risk factors for eating pathology have not received empirical support (e.g., sexual abuse) or have received contradictory support (e.g.. dieting). Ther...

Tanaka, K.L.; Hartmann, W.K., 2008: The planetary time scale. Time scales for extraterrestrial planetary surfaces permit correlation of geologic events across the solar system. These time scales are primarily based on robotic exploration of planetary surfaces over the past half century but are also criticall...

Anonymous, 2003: High P-T phase relations and stability of a (21)-hydrous clinopyribole in the system K (sub 2) O-Na (sub 2) O-CaO-MgO-Al (sub 2) O (sub 3) -SiO (sub 2) -H (sub 2) O; an experimental study to 18 GPa. Phase relations and stability of a mixed-chain (21)-hydrous clinopyribole [(21)-MHP] were investigated using a multi-anvil apparatus in the P-T range 5-18 GPa and 1100-1600 degrees C in a simplified KNCMASH-system. (21)-MHP is stable in the range...