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Cyclosporin A: early or delayed onset by prophylactic immunosuppression?


, : Cyclosporin A: early or delayed onset by prophylactic immunosuppression?. Nephrology, Dialysis, Transplantation 8(4): 366-368

In a prospective randomized trial, 57 renal transplant patients received sequential immunosuppression consisting of lymphocytoglobulin (ALG), azathioprine, and steroids for 14 days (group A) and another 57 patients for only 2 days (group B). In each case therapy was continued with cyclosporin A and steroids. The purpose of this study was to find the most favourable time to switch over to continuous cyclosporin A therapy with advoidance of its nephrotoxic side-effects during the perioperative phase. As a consequence of ALG intolerance, conventional immunosuppression had to be changed in group A after a mean of 7.8 days, as opposed to 2.1 days in group B. The patients receiving a prophylactic therapy with ALG, azathioprine, and steroids for 14 days (group A) had to be dialysed at a significantly greater frequency than patients with an early start to cyclosporin A (group B) from the second to the fourth week. Patient survival rates 1 and 2 years after transplantation of group A (95 and 92%) and group B (96 and 92%) were not distinct, and there was no significant difference in graft survival rates of group A (79 and 79%) and B (89 and 82%) after the same time. A delayed start of cyclosporin A after 14 days showed no further advantage but rather a significantly greater frequency of dialysis; thus the early onset of cyclosporin A treatment post-transplant is preferable.

US$29.90

PMID: 8390014


Other references

McComb, M.N.; Collins, C.D., 2015: Comparative cost-effectiveness of alternative empiric antimicrobial treatment options for suspected enterococcal bacteremia. Enterococcus species are the fourth leading cause of bacteremia. Resistance rates are rising and delays in appropriate initial antimicrobial therapy have been associated with increased mortality. Empiric treatment of patients with suspected entero...

Eng, C.P.; Kleine, L.P.; Morgan, J.F., 1970: Tumor-specific immunity induced by nontumorigenic 6C3HED ascites tissue culture cells. Journal of the National Cancer Institute 45(2): 235-242

Ioannou, Y.; Desnick, R.J.; Sandrin, M.S.; Mckenzie, I.F.C., 2002: Cells expressing an alphagala nucleic acid and methods of xenotransplantation. The present invention relates to methods and compositions for the reduction of xenotransplantation rejection. Specifically, the present invention relates, first, to transgenic cells, tissues, organs and animals containing transgenic nucleic acid m...

Laisse, Cáudio.J.M.; Gavier-Widén, D.; Ramis, G.; Bila, Códio.G.; Machado, A.; Quereda, J.J.; Agren, E.O.; van Helden, P.D., 2012: Characterization of tuberculous lesions in naturally infected African buffalo (Syncerus caffer). Tuberculosis pathology was studied on 19 African buffalo (Syncerus caffer) from a herd in the Hluhluwe-iMfolozi Park in South Africa. The animals tested positive with the comparative intradermal tuberculin test and were euthanized during a test-an...

Colao, A.; Loche, S., 2010: Prolactinomas in children and adolescents. Prolactinomas are the most common pituitary adenomas in children and adolescents followed by adrenocorticotropic hormone-secreting and growth hormone-secreting adenomas. Females are slightly more affected than males (who have macroadenomas more fr...

Podder, M.; Ruan, J.; Tripp, B.W.; Chu, Z.E.; Tebbutt, S.J., 2008: Robust SNP genotyping by multiplex PCR and arrayed primer extension. Arrayed primer extension (APEX) is a microarray-based rapid minisequencing methodology that may have utility in 'personalized medicine' applications that involve genetic diagnostics of single nucleotide polymorphisms (SNPs). However, to...

Ancion Charles; Noel R.; Stassen P., 1956: Galets de charbon en connexion avec un wash-out au Charbonnage Cockerill, a Seraing. A study of the petrography and physicochemical composition of wellrounded pebbles of coal found in the vicinity of a washout in the seam of the mine at Seraing in the Liege basin, Belgium, shows that the coal of the pebbles is similar to that in t...

Ying, X.; Han, S-xia.; Wang, J-lan.; Zhou, X.; Jin, G-hua.; Jin, L.; Wang, H.; Wu, L.; Zhang, J.; Zhu, Q., 2014: Serum peptidome patterns of hepatocellular carcinoma based on magnetic bead separation and mass spectrometry analysis. Hepatocellular carcinoma (HCC) is one of the most common cancers in the world,and the identification of biomarkers for the early detection is a relevant target. The purpose of the study is to discover specific low molecular weight (LMW) serum pept...

Lashchinskii, N.N.J.; Troitskaya, N.I., 1992: Plants discovered in Barguzin Reserve. Of the 778 species recorded from the reserve, 70 are reported for the first time, including Poa altaica, P. sabulosa [P. pratensis], P. urssulensis, Elymus confusus, Astragalus trigonocarpus, Oxytropis sajanensis and O. sylvatica.

Young, A.E., 1989: Selection of patients for breast conservation. British Journal of Surgery 76(9): 885-885