+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Debrisoquine and mephenytoin oxidation in Sinhalese: A population study

, : Debrisoquine and mephenytoin oxidation in Sinhalese: A population study. British Journal of Clinical Pharmacology 38(5): 466-470

The frequency distributions of the 0-8 h urinary metabolic ratios of debrisoquine and mephenytoin were measured in 111 healthy, unrelated Sinhalese resident in Sri Lanka. Blood samples were taken from 77 of these subjects for CYP2D6 genotyping. Bimodality in the distribution of the log-10 debrisoquine/4-hydroxydebrisoquine ratio was not evident from visual inspection and by kernel density analysis. The results of genotyping indicated that 82% of the population were either homozygous for the wild-type CYP2D6 gene or heterozygous for the wild type allele and the whole gene deletion. Eighteen per cent of the Sinhalese population were heterozygous for the CYP2D6B mutation and the wild-type allele. All of these genotypes give rise to the extensive metaboliser phenotype in white Caucasians. No CYP2D6A mutations were identified and no individuals who were homozygous for the mutant alleles were detected, which is in accord with an absence of phenotypic poor metabolisers of debrisoquine. The mutant CYP2D6 allele frequency in Sinhalese (9%) is only half that observed in white Caucasians. The S/R-mephenytoin ratio ranged from 0.09 to 2.27 (median 0.38). By visual inspection and kernel density analysis the distribution of the S/R-mephenytoin ratio was bimodal and, using a value of 0.9 for the antimode, 16 (14%) subjects were poor metabolisers. In conclusion, the prevalence of the poor metaboliser phenotype in Sinhalese appears much lower for debrisoquine and higher for mephenytoin than in white Caucasians. These findings are similar to those observed in Indians living in Bombay and in Oriental populations.


PMID: 7893590

DOI: 10.1111/j.1365-2125.1994.tb04384.x

Other references

Boldt, H.C.lver; Munden, P.M.; Folk, J.C.; Mehaffey, M.G., 1996: Visual field defects after macular hole surgery. PURPOSE: To describe a group of patients with dense visual field defects following macular hole surgery. METHODS: Nine (7%) of 125 patients reviewed noted onset of dense visual field defects following uncomplicated vitrectomy with gas-fluid exchan...

McComas, A.J.; Campbell, M.J.; Sica, R.E., 1971: Electrophysiological study of dystrophia myotonica. A comprehensive electrophysiological study has been made of the extensor digitorum brevis muscle and its motor innervation in 17 patients with dystrophia myotonica. The mean contraction and half-relaxation times were prolonged in the isometric twi...

Maekawa, N.; Nishina, K.; Mikawa, K.; Obara, H., 1992: High-frequency oscillation may be useful in perioperative respiratory management of neonates with congenital cystic adenomatoid malformation. Anesthesiology 77(5): 1051-1052

Cameron, Rb, 1981: Bank lending to the rural sector. Commodity bulletin New South Wales Department of Agriculture Division of keting and Economics 10(12): 1-12

Khan P.M.; Brahe C.; Wijnen L.M.M., 1984: Gene map of dog 6 conserved and 3 disrupted syntenies. Cytogenetics & Cell Genetics 37(1-4): 537-538

Pritchard, Hugh W., 1994: Seeds in the freezer 1993 Society for Low Temperature Biology meeting, Chelwood Gate, Sussex, UK September 14-16,. Cryo Letters 15(2): 77-79

Hiraguchi, Y.; Nagahashi, K.; Shibayama, T.; Hayashi, T.; Yano, T-aki.; Kushiro, K.; Takai, M., 2015: Effect of the distribution of adsorbed proteins on cellular adhesion behaviors using surfaces of nanoscale phase-reversed amphiphilic block copolymers. In order to create suitable biocompatible materials for various tissue engineering applications, it is important to be able to understand protein adsorption and cell adhesion behaviors on the material's surfaces. It is known that the nanoscal...

Morenas, R.L., 1926: Ana-phylaxis in intestinal helminthiasis Clinical facts and pathology. The author, inspired by the studies of Weinberg and his pupils, and of Simonin, in causing anaphylactic reactions by injecting extracts of worms into animals, has tried to get an experimental, verminous anaphylaxis resembling as nearly as possible...

Mori, T.; Kitagawa, T.; Okumura, Y.; Ueda, T., 1969: Conformation therapy technique with a 6MeV linear accelerator for cervical cancer. Treatment planning. Gan No Rinsho. Japan Journal of Cancer Clinics 15(12): 1047-1051

Jawale, A.K.; Patel, R.J., 2002: Some species of Bulbochaete Agardh from Gujarat, India. Geobios (Jodhpur) 29(4): 269-270, October