+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Decreased central histamine in the amygdaloid kindling rats

, : Decreased central histamine in the amygdaloid kindling rats. Brain Research. 802(1-2): 241-246,. 17

This study was conducted to elucidate the role of central histamine (HA) in seizure susceptibility. We stimulated the left amygdala of rats to produce amygdaloid kindling. We sacrificed rats 1 h, 1 week and 1 month after the last kindled seizure, and measured the histamine contents and the histidine decarboxylase (HDC) activities of various brain regions. One hour after the last kindled seizure, we found significant decreases in HA levels in the bilateral amygdala, hippocampus and diencephalon in the kindled group. The HDC activities of the bilateral amygdala and diencephalon were lower in the kindled group than in the control group. One week after the last kindled seizure, we also found a significant decrease in the HA level in the bilateral amygdala. No significant change was found in HA content or HDC activity 1 month after the last kindled seizure. These results suggest that kindling suppresses HA synthesis and that the reduced HA content is maintained until 1 week after the last kindled seizure. The reduced HA may play a role in the acquired kindled seizure susceptibility.


PMID: 9748604

DOI: 10.1016/s0006-8993(98)00637-4

Other references

Lanca, I., 1983: Prospects of development in the forage crops harvesting machines. Mechanizace zemedelstvi3(5): 211-213

Stirban, M.A.bu, N., 1979: Biosynthesis and accumulation of assimilatory pigments in maize plants from seeds treated with ultrasonics and microelements. Contributii botanice: 71-276

Süss, J., 1971: Elementary classification of variations in human dentition. (II). Die Quintessenz 22(8): 107-112

Spitale, R.C.; Wedekind, J.E., 2009: Exploring ribozyme conformational changes with X-ray crystallography. Relating three-dimensional fold to function is a central challenge in RNA structural biology. Toward this goal, X-ray crystallography has long been considered the "gold standard" for structure determinations at atomic resolution, althoug...

Rahman M.F.; Jairajpuri M.S.; Ahmad I.; Ahmad W., 1986: Two new species of labronema thorne 1939 nematoda dorylaimida from india. Two new species of Labronema Throne, 1939 are described and illustrated. Labronema neopacificum n. sp. is 2.38-2.74 mm long, with a = 28-32; b = 4.0-4.5; c = 82.95; V = 51-54; odontostyle = 35-36 .mu.m and is closely related to L. pacificum (Cobb,...

Diwan, AD.; Joseph, S., 1999: Cryopreservation of spermatophores of the marine shrimp, Penaeus indicus H. Milne Edwards. Indian Journal of Fisheries, 462: 159-166

Boreham, P.F.; Facer, C.A., 1974: Studies on the fibrinolytic system of rabbits infected with Trypanosoma (Trypanozoon) brucei. Parasitology 69(2): Xxv-Xxv

Kiel, W., 1967: Four years of tests of potato varieties for resistance to S. scabies. Twenty-two varieties were tested and results are given as percentage attacked for the years 1963-66. The most resistant were Kastor, Auriga, and Stieglitz in this order. The results are in general agreement with those for the previous four years w...

Coude, F.X.; Ogier, H.; Charpentier, C.; Cathelineau, L.; Grimber, G.; Parvy, P.; Saudubray, J.M.; Frezal, J., 1981: Lysinuric protein intolerance: a severe hyperammonemia secondary to l-arginine deficiency ]. Lysinuric protein intolerance is an autosomal recessive disease, due to a defect in intestinal, renal and hepatic dibasic amino acid transport. Two new cases in the same family are reported. The disease appears progressively during the first month...

Robinson, M.L., 1987: Patient "dumping" regulations offer little guidance. Hospitals 61(17): 35-36