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Defining candidate genes for mastitis resistance in cattle: The role of lactoferrin and lysozyme


, : Defining candidate genes for mastitis resistance in cattle: The role of lactoferrin and lysozyme. Journal of Animal Breeding and Genetics 113(4-5): 269-276

We summarize our previous and ongoing efforts to characterize two potential candidate genes (lactoferrin and lysozyme) for mastitis resistance and examine their relevance for an improvement of udder-health in cows. The genes encoding lactoferrin (Lf) and lysozyme (Lys) have been isolated and characterized at the DNA-sequence level, besides the alpha-S1-casein gene. Starting from these data, two different strategies are being persued to analyse their relevance in breeding for mastitis resistance. First, based on the molecular characterization of their natural variants we are searching for high-performance alleles of both genes in the active breeding population. A first trend for the implication of a Lf-gene variant in mastitis-resistance is seen in the Norwegian breeding population. Second, we want to assess experimentally the value of these genes for mastitis resistance under physiological conditions in transgenic experiments, under expression control of the bovine alpha-S1-casein gene promoter. Based upon extensive molecular and cell biological characterizations of the bovine alpha-S1-casein gene and its regulatory elements, a vector cassette has been constructed for transgene expression in the mammary gland. Positive expression of a lactoferrin expressing transgene in the mammary gland of mice has been demonstrated.

US$19.90

DOI: 10.1111/j.1439-0388.1996.tb00616.x


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