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Dependence of maximum performance time on working intensity in patients with a hereditary myopathy with succinate dehydrogenase deficiency


, : Dependence of maximum performance time on working intensity in patients with a hereditary myopathy with succinate dehydrogenase deficiency. Clinical Physiology (Oxford) 12(5): 567-573

Patients with a hereditary mitochondrial myopathy with succinate dehydrogenase (SDH) deficiency and abnormal lactacidosis during physical exercise have a low work capacity when exercising for about 10-15 min. Their maximum voluntary muscular strength is fairly normal. The relationship between the time (t) and a constant workload (N) that a healthy subject can maximally sustain can be expressed as: log t = beta + alpha log N. For normal subjects the constant alpha is approximately -5 and the constant beta has a large interindividual variation. Of four myopathy patients alpha was determined from two or three maximum bicycle exercise tests of different duration (including ramp- and steady-state tests using a new application of the method of adding submaximal loads to the final maximum workload). The value of alpha varied between -1.0 and 1.81 and beta had low values, both significantly different from those of healthy subjects. The alpha values explain the divergent results that may be obtained with different types of exercise tests in some of these patients, i.e. a normal or moderately reduced capacity in exercise tests of short duration (for example a short Tornvall or a ramp type of test) and a very low exercise capacity in tests of longer duration (for example a steady state type of test with workloads chosen to allow at least two loads). The low absolute value of alpha may be related to the abnormally increased anaerobic metabolism of these patients during exercise, caused by the SDH deficiency.

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Other references

Anan'eva, T.G., 1978: Barotherapy of the burned. Klinicheskaia Khirurgiia: 49-51

Corte Real M.; Leao C., 1992: Deacidification of grape juice with derepressed mutants of the yeast hansenula anomala. Transport and utilization of malic acid by the yeast Hansenula anomala are subject to glucose repression. Derepressed diploid mutant strains were obtained by hybridization of derepressed haploid mutant strains of opposite mating type. Six diploid...

Lillie, R.D., 1961: Metal chelate reaction of enterochromaffin. Enterochromaffin slowly binds ferrous ions at pH levels between 3.5 and 5.0 and gives them up again at low pH levels (1-2.5). Ferrous ions so bound may be demonstrated in situ by action of potassium ferricyanide, probably by acid dissociation of t...

Yu. I.C.ekanova; L.V.R.abova, 1981: Interaction between syngeneic hematopoietic stem cells and lymphocytes in leukemic akr mice. The syngeneic donor-recipient model was used to examine the influence of T lymphocytes from AKR mice with spontaneous leukemia on colony formation and differentiation of hemopoietic stem cells. In the stage of neoplastic process development, the c...

Richards, N.D.; Söderholm, K-Johann.; Batich, C.D., 2004: Effect of molar mass of an experimental primer on shear bond strength to dentin. A novel oligomer was synthesized in different molecular masses and used as a primer in dentin bonding. The hypothesis was that an intermediate molecular mass would optimize the conflicting needs for diffusion into etched dentin (low Mw) and high m...

Bower S.G.; Switzer R.L., 1986: Cloning of the salmonella typhimurium phosphoribosylpyrophosphate synthetase gene prs a. Federation Proceedings 45(6): 1894

Lyonnet, D.; Pinet, F.; Nahum, H.; Tavernier, J.; Frija, G., 1987: Postgraduate education in radiodiagnosis: a necessity. Journal de Radiologie 68(3): 157-158

Fujimoto, S.; Murakami, K.; Ohara, A., 1985: The presence of essential histidine residues in manganese iii containing acid phosphatase ec 3.1.3.2 from sweet potato. Chemical modification studies of Mn(III)-containing acid phosphatase [EC 3.1.3.2] were carried out to investigate the contributions of specific amino-acid side chains to the catalytic activity. Incubation of the enzyme with N-ethylmaleimide at pH...

Lii C Y.; Lee K.M.; Chang C.K., 1992: The correlations between the physiochemical properties as well as the structures of the amylopectins and the eating qualities of rices in taiwan. Cereal Foods World 37(7): 572

Ahluwalia A.D., 1989: Geological notes based on remapping of a part of Shali Window with special emphasis on its potential for cement grade limestone. Contributions to Himalayan Geology 4: 210-219