geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Desensitization of beta-adrenergic responses in adipocytes involves receptor subtypes and cAMP phosphodiesterase


, : Desensitization of beta-adrenergic responses in adipocytes involves receptor subtypes and cAMP phosphodiesterase. European Journal of Pharmacology 289(2): 235-247

Acute exposure of isolated adipocytes to isoproterenol induces the desensitization of lipolytic responses to norepinephrine and selective beta-1-, beta-2-- and beta-3-adrenoceptor agonists, as well as the adrenocorticotropic hormone 1-24 fragment (ACTH). Forskolin and 8-bromo-cAMP responses are also desensitized. When lipolysis was measured in the presence of OPC 3911 (N-cyclohexyl-N-2-hydroxyethyl-4(6-(1,2-dihydro-2-oxoquinolyloxy))butyramide), a specific inhibitor of the cAMP phosphodiesterase of adipocytes, the desensitization of all lipolytic agents -- except the beta-2-adrenoceptor agonist - was abolished. Isoproterenol induced a similar loss (35%) of both membrane beta-1- and beta-2-adrenoceptors and an uncoupling of beta-1-adrenoceptors, but did not modify the weak coupling of control beta-2-adrenoceptors. These data suggest that isoproterenol induced (i) an activation of the cAMP phosphodiesterase, which is solely responsible for the desensitization of norepinephrine response as well as beta-1- and beta-3-adrenoceptor mediated responses and (ii) an additional desensitization of the sole beta-2-adrenergic signaling system which suggests a subtype-selective pattern of regulating processes.

US$29.90

PMID: 7621897


Other references

Prasad, K.; Gupta, J.B., 1993: Influence of hydroxyl radical on rabbit airway smooth muscle chronically exposed to H2O2 in vivo. The effects of OH on the isolated tracheal smooth muscles (TSM), from control, polyethylene glycol (PEG)-glucose oxidase (GO)-, and GO + PEG catalase-treated rabbits were investigated. GO or GO + catalase were given intravenously each week for 4 m...

Orozco-del-Castillo, M.G.; Ortiz-Aleman, C.; Urrutia-Fucugauchi, J.; Rodriguez-Castellanos, A., 2011: Fuzzy logic and image processing techniques for the interpretation of seismic data. Since interpretation of seismic data is usually a tedious and repetitive task, the ability to do so automatically or semi-automatically has become an important objective of recent research. We believe that the vagueness and uncertainty in the inte...

Laitinen, S.; Kangas, J.; Husman, K.; Susitaival, P., 2001: Evaluation of exposure to airborne bacterial endotoxins and peptidoglycans in selected work environments. The aim of this study was to assess workers' exposure to endotoxins and peptidoglycans, as well as associations between workers' reported symptoms and the detected bacterial exposures. From the filter samples, biologically-active endotox...

Luka ?. Popovi?, 2012: Super-massive binary black holes and emission lines in active galactic nuclei. It is now agreed that mergers play an essential role in the evolution of galaxies and therefore that mergers of supermassive black holes (SMBHs) must have been common. We see the consequences of past supermassive binary black holes (SMBs) in the l...

Varma, S.D.; Hegde, K.R., 2010: Prevention of oxidative damage to lens by caffeine. The primary objective of this study was to examine the possibility of inhibiting oxidative damage to the lens in vitro by caffeine. Oxidative damage was inflicted by incubating mouse lenses in Tyrode medium containing 0.1 mM Fe(8)Br(8), an iron co...

Nichols K.; Prigent F.; Thomas C.; Maddahi J., 1990: Quantification of myocardial mass by technetium 99m mibi gated single photon emission computed tomography in a canine model. Clinical Nuclear Medicine 15(10): 767

Kukla J., 1969: The cause of the Holocene climate change. Climatic trends, sedimentary cycles in loess series, deep-sea sediments, cyclic insolation changes, astronomic periodicity correlation with glacial-interglacial cycles, terrestrial heat budget, position of mean snow line, interaction of albedo and...

Biringen, Z.; Robinson, J.L.; Emde, R.N., 2001: Appendix A: the emotional availability scales (2nd ed.; an abridged infancy/Early Childhood version). Attachment & Human Development 2(2): 251-270

Unz, R.F.; Farrah, S.R., 1976: Exopolymer production and flocculation by zoogloea mp6. Flocculation by Zoogloea MP6 was accompanied by the production of a mucopolysaccharide exopolymer. Polymer formation was initiated in mid-logarithmic growth phase, and the quantity produced appeared to be influenced by the level of carbon and nitr...

Ayala R.; Becerra A.; Iribarne L.; Diaz J.R.; Bienvenido F.; Bosch A., 1996: The Estiara GIS; a geographic information system for decision-making support in rural planning. Mapping (Madrid) 34: 90-95