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Design and synthesis of curacin A analogs with varied side chain structures

, : Design and synthesis of curacin A analogs with varied side chain structures. Bioorganic & Medicinal Chemistry Letters. 7(20): 2657-2660,. 21

A series of side chain-modified analogs of curacin A, a powerful antimitotic agent isolated from a Caribbean cyanobacterium was synthesized and the effect of these compounds on in vitro microtubule polymerization was examined. The analogs showed weak or no anti-tubulin activity, suggesting that the whole side chain structure of curacin A is required for the interaction with tubulin.


DOI: 10.1016/s0960-894x(97)10055-5

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